Pathology · USMLE Step 1

USMLE Pathology: Musculoskeletal and Dermatologic System

Bone tumor morphology, connective tissue disease histology, and classic skin biopsy findings, one finding per card.

39 cards · basic cards · AI-written, checked twice. Edit anything.

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Which bone tumor classically shows a Codman triangle on X-ray?
Osteosarcoma
What X-ray pattern of periosteal new bone formation is classic for osteosarcoma?
Sunburst pattern
Osteosarcoma most commonly arises in which part of a long bone?
The metaphysis, often around the knee
What is the most common benign bone tumor?
Osteochondroma
What small, painful bone lesion has a central nidus and improves with NSAIDs?
Osteoid osteoma
A 'soap bubble' lytic lesion in the epiphysis near the knee suggests which tumor?
Giant cell tumor of bone
What characteristic cell type gives giant cell tumor of bone its name?
Multinucleated osteoclast-like giant cells
What periosteal reaction pattern on X-ray is classic for Ewing sarcoma?
Onion-skin (lamellated) periosteal reaction
Ewing sarcoma is composed histologically of ____.
small round blue cells
What chromosomal translocation is characteristic of Ewing sarcoma?
t(11;22)
What is the malignant cartilage-forming bone tumor called?
Chondrosarcoma
What benign tumor of hyaline cartilage arises within the medullary cavity, often in the hands?
Enchondroma
What bone lesion shows a 'ground glass' appearance on X-ray?
Fibrous dysplasia
In fibrous dysplasia, the woven bone trabeculae have a histologic pattern described as ____.
Chinese letters
In SLE, concentric periarterial fibrosis in the spleen produces what classic finding?
Onion-skin lesions

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