Pathology · USMLE Step 1

USMLE Pathology: Pulmonary System

Gross and microscopic lung pathology including obstructive versus restrictive disease patterns, pneumonia types, and pulmonary vascular disease. Original cards testing the underlying concepts.

40 cards · basic cards · AI-written, checked twice. Edit anything.

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PFT hallmark of obstructive lung disease
Decreased FEV1/FVC ratio
Two diseases that together make up COPD
Chronic bronchitis and emphysema
Clinical definition of chronic bronchitis
Productive cough for at least 3 months in each of 2 consecutive years
In chronic bronchitis, does the Reid index increase or decrease?
Increases
Most common cause of centriacinar emphysema
Cigarette smoking
Panacinar emphysema is classically associated with which deficiency
Alpha-1 antitrypsin deficiency
Mechanism of alveolar wall destruction in alpha-1 antitrypsin deficiency
Unopposed neutrophil elastase destroys elastin in the alveolar walls
Asthma is classically what type of hypersensitivity reaction
Type I (IgE-mediated) hypersensitivity
Definition of bronchiectasis
Permanent dilation of bronchi and bronchioles caused by chronic necrotizing infection or inflammation
PFT hallmark of restrictive lung disease
Decreased total lung capacity with a normal or increased FEV1/FVC ratio
Two general categories of restrictive lung disease
Poor chest wall or neuromuscular mechanics, and interstitial lung disease
Histologic pattern classically seen in idiopathic pulmonary fibrosis
Usual interstitial pneumonia (UIP)
Characteristic gross lung finding in idiopathic pulmonary fibrosis
Honeycomb lung
Definition of pneumoconiosis
Interstitial lung fibrosis caused by inhalation of occupational dusts or particles
Silicosis produces what characteristic finding in the hilar lymph nodes
Eggshell calcification

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