Soft tissue sarcoma classification and morphology, distinct from the bone-tumor focus of the musculoskeletal and dermatologic pathology deck.
32 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common soft tissue sarcoma in adults overall?
- Liposarcoma
- What is the most common soft tissue sarcoma in children?
- Rhabdomyosarcoma
- Well-differentiated liposarcoma is characterized by amplification of which gene?
- MDM2
- What chromosomal translocation and fusion gene characterize myxoid liposarcoma?
- t(12;16) producing a DDIT3-FUS fusion
- Myxoid liposarcoma shows what characteristic vascular pattern on histology?
- A branching, 'chicken-wire' pattern of thin capillaries within myxoid stroma
- How does pleomorphic liposarcoma compare in grade to other liposarcoma subtypes?
- It is the highest-grade liposarcoma subtype
- Which rhabdomyosarcoma subtype is the most common overall?
- Embryonal rhabdomyosarcoma
- Embryonal rhabdomyosarcoma most commonly arises in which body regions?
- The head and neck, and the genitourinary tract
- What is the botryoid variant of embryonal rhabdomyosarcoma?
- A grape-like mass arising in hollow organs such as the vagina or bladder
- What translocation and fusion gene characterize alveolar rhabdomyosarcoma?
- t(2;13) producing a PAX3-FOXO1 fusion
- How does alveolar rhabdomyosarcoma differ from embryonal rhabdomyosarcoma in site and prognosis?
- It typically arises in the extremities of adolescents and carries a worse prognosis
- Which two immunohistochemical markers confirm rhabdomyoblast (skeletal muscle) differentiation?
- Desmin and myogenin
- What morphologic feature is classic for a rhabdomyoblast on H&E?
- Eosinophilic cytoplasm with visible cross-striations
- What are the two most common anatomic sites for leiomyosarcoma?
- The retroperitoneum and the uterus
- What nuclear feature characterizes the spindle cells of leiomyosarcoma?
- Blunt-ended, 'cigar-shaped' nuclei