Soft tissue sarcoma classification and morphology, distinct from the bone-tumor focus of the musculoskeletal and dermatologic pathology deck.
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- What is the most common soft tissue sarcoma in adults overall?
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Liposarcoma- What is the most common soft tissue sarcoma in children?
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Rhabdomyosarcoma- Well-differentiated liposarcoma is characterized by amplification of which gene?
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MDM2- What chromosomal translocation and fusion gene characterize myxoid liposarcoma?
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t(12;16) producing a DDIT3-FUS fusion- Myxoid liposarcoma shows what characteristic vascular pattern on histology?
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A branching, 'chicken-wire' pattern of thin capillaries within myxoid stroma- How does pleomorphic liposarcoma compare in grade to other liposarcoma subtypes?
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It is the highest-grade liposarcoma subtype- Which rhabdomyosarcoma subtype is the most common overall?
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Embryonal rhabdomyosarcoma- Embryonal rhabdomyosarcoma most commonly arises in which body regions?
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The head and neck, and the genitourinary tract- What is the botryoid variant of embryonal rhabdomyosarcoma?
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A grape-like mass arising in hollow organs such as the vagina or bladder- What translocation and fusion gene characterize alveolar rhabdomyosarcoma?
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t(2;13) producing a PAX3-FOXO1 fusion- How does alveolar rhabdomyosarcoma differ from embryonal rhabdomyosarcoma in site and prognosis?
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It typically arises in the extremities of adolescents and carries a worse prognosis- Which two immunohistochemical markers confirm rhabdomyoblast (skeletal muscle) differentiation?
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Desmin and myogenin- What morphologic feature is classic for a rhabdomyoblast on H&E?
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Eosinophilic cytoplasm with visible cross-striations- What are the two most common anatomic sites for leiomyosarcoma?
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The retroperitoneum and the uterus- What nuclear feature characterizes the spindle cells of leiomyosarcoma?
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Blunt-ended, 'cigar-shaped' nuclei
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