Classic paraneoplastic syndromes matched to the tumor type that causes them and the underlying mechanism, a cross-cutting oncology concept deck.
30 cards · basic cards · AI-written, checked twice. Edit anything.
- Which lung cancer subtype is most classically associated with SIADH?
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Small cell lung carcinoma.- Small cell lung carcinoma causes SIADH by ectopic secretion of ____.
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ADH (antidiuretic hormone)- Which lung cancer subtype is most classically associated with ectopic Cushing syndrome?
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Small cell lung carcinoma.- Small cell lung carcinoma causes ectopic Cushing syndrome by secreting ____.
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ACTH- Which lung cancer subtype most classically causes hypercalcemia of malignancy?
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Squamous cell lung carcinoma.- Squamous cell lung carcinoma causes hypercalcemia of malignancy by secreting ____.
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PTHrP (parathyroid hormone-related peptide)- How does PTHrP raise serum calcium?
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It binds PTH receptors, increasing bone resorption and renal calcium reabsorption.- In multiple myeloma, hypercalcemia results from what mechanism, distinct from PTHrP?
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Direct osteolytic bone destruction from cytokine-driven osteoclast activation.- Lambert-Eaton myasthenic syndrome is most strongly associated with which tumor?
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Small cell lung carcinoma.- Lambert-Eaton myasthenic syndrome is caused by autoantibodies against presynaptic ____.
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voltage-gated calcium channels- Unlike myasthenia gravis, does muscle strength in Lambert-Eaton myasthenic syndrome improve or worsen with repeated stimulation?
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Improves with repeated stimulation.- Paraneoplastic cerebellar degeneration with anti-Yo antibodies is most associated with which cancers?
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Ovarian and breast cancer.- Anti-Hu antibodies are most classically associated with which tumor?
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Small cell lung carcinoma.- What paraneoplastic neurologic syndrome is anti-Hu antibody associated with?
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Sensory neuropathy and encephalomyelitis.- Anti-Ri antibodies causing opsoclonus-myoclonus in adults are most associated with which cancers?
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Breast and lung cancer.
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