Classic paraneoplastic syndromes matched to the tumor type that causes them and the underlying mechanism, a cross-cutting oncology concept deck.
30 cards · basic cards · AI-written, checked twice. Edit anything.
- Which lung cancer subtype is most classically associated with SIADH?
- Small cell lung carcinoma.
- Small cell lung carcinoma causes SIADH by ectopic secretion of ____.
- ADH (antidiuretic hormone)
- Which lung cancer subtype is most classically associated with ectopic Cushing syndrome?
- Small cell lung carcinoma.
- Small cell lung carcinoma causes ectopic Cushing syndrome by secreting ____.
- ACTH
- Which lung cancer subtype most classically causes hypercalcemia of malignancy?
- Squamous cell lung carcinoma.
- Squamous cell lung carcinoma causes hypercalcemia of malignancy by secreting ____.
- PTHrP (parathyroid hormone-related peptide)
- How does PTHrP raise serum calcium?
- It binds PTH receptors, increasing bone resorption and renal calcium reabsorption.
- In multiple myeloma, hypercalcemia results from what mechanism, distinct from PTHrP?
- Direct osteolytic bone destruction from cytokine-driven osteoclast activation.
- Lambert-Eaton myasthenic syndrome is most strongly associated with which tumor?
- Small cell lung carcinoma.
- Lambert-Eaton myasthenic syndrome is caused by autoantibodies against presynaptic ____.
- voltage-gated calcium channels
- Unlike myasthenia gravis, does muscle strength in Lambert-Eaton myasthenic syndrome improve or worsen with repeated stimulation?
- Improves with repeated stimulation.
- Paraneoplastic cerebellar degeneration with anti-Yo antibodies is most associated with which cancers?
- Ovarian and breast cancer.
- Anti-Hu antibodies are most classically associated with which tumor?
- Small cell lung carcinoma.
- What paraneoplastic neurologic syndrome is anti-Hu antibody associated with?
- Sensory neuropathy and encephalomyelitis.
- Anti-Ri antibodies causing opsoclonus-myoclonus in adults are most associated with which cancers?
- Breast and lung cancer.