Renal cell carcinoma and other renal tumor morphology and paraneoplastic associations, one finding per card.
29 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common primary renal malignancy in adults?
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Renal cell carcinoma (RCC)- From which renal cell type does renal cell carcinoma arise?
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Proximal tubule epithelial cells- What is the classic triad of renal cell carcinoma?
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Flank pain, hematuria, and a palpable abdominal mass- What is the most common histologic subtype of renal cell carcinoma?
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Clear cell renal cell carcinoma- What color is clear cell RCC on gross examination?
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Golden yellow- Why does clear cell RCC have clear-appearing cytoplasm on histology?
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Accumulation of glycogen and lipid that dissolves out during tissue processing- What characteristic vasculature pattern is seen in clear cell RCC?
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A delicate, branching "chicken-wire" vasculature- Loss of which gene is characteristic of clear cell RCC?
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The VHL (von Hippel-Lindau) tumor suppressor gene- On which chromosome arm is the VHL gene located?
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3p (short arm of chromosome 3)- What is the inheritance pattern of von Hippel-Lindau disease?
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Autosomal dominant- What CNS/retinal tumor is associated with von Hippel-Lindau disease?
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Hemangioblastoma- What adrenal medullary tumor is associated with von Hippel-Lindau disease?
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Pheochromocytoma- What is the strongest modifiable risk factor for renal cell carcinoma?
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Cigarette smoking- What renal tumor risk is increased by long-term dialysis?
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RCC arising in acquired (dialysis-associated) cystic kidney disease- Ectopic secretion of what hormone by RCC causes paraneoplastic polycythemia?
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Erythropoietin (EPO)
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