Renal cell carcinoma and other renal tumor morphology and paraneoplastic associations, one finding per card.
29 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common primary renal malignancy in adults?
- Renal cell carcinoma (RCC)
- From which renal cell type does renal cell carcinoma arise?
- Proximal tubule epithelial cells
- What is the classic triad of renal cell carcinoma?
- Flank pain, hematuria, and a palpable abdominal mass
- What is the most common histologic subtype of renal cell carcinoma?
- Clear cell renal cell carcinoma
- What color is clear cell RCC on gross examination?
- Golden yellow
- Why does clear cell RCC have clear-appearing cytoplasm on histology?
- Accumulation of glycogen and lipid that dissolves out during tissue processing
- What characteristic vasculature pattern is seen in clear cell RCC?
- A delicate, branching "chicken-wire" vasculature
- Loss of which gene is characteristic of clear cell RCC?
- The VHL (von Hippel-Lindau) tumor suppressor gene
- On which chromosome arm is the VHL gene located?
- 3p (short arm of chromosome 3)
- What is the inheritance pattern of von Hippel-Lindau disease?
- Autosomal dominant
- What CNS/retinal tumor is associated with von Hippel-Lindau disease?
- Hemangioblastoma
- What adrenal medullary tumor is associated with von Hippel-Lindau disease?
- Pheochromocytoma
- What is the strongest modifiable risk factor for renal cell carcinoma?
- Cigarette smoking
- What renal tumor risk is increased by long-term dialysis?
- RCC arising in acquired (dialysis-associated) cystic kidney disease
- Ectopic secretion of what hormone by RCC causes paraneoplastic polycythemia?
- Erythropoietin (EPO)