Gynecologic and testicular tumor classification, cervical dysplasia grading, and placental pathology, one finding per card. Original cards testing the underlying concepts.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- Which two HPV genotypes carry the highest risk for cervical cancer?
- HPV 16 and 18.
- Which two HPV genotypes most commonly cause condyloma acuminatum (genital warts)?
- HPV 6 and 11.
- What cytologic finding on Pap smear is the hallmark of HPV-infected squamous cells?
- Koilocytes (cells with perinuclear halos and irregular, raisinoid nuclei).
- In CIN I, what fraction of the epithelial thickness shows dysplastic cells?
- The lower third of the epithelium.
- In CIN II, what fraction of the epithelial thickness shows dysplastic cells?
- The lower two-thirds of the epithelium.
- In CIN III, what fraction of the epithelial thickness shows dysplastic cells?
- The full thickness of the epithelium (carcinoma in situ).
- What is the most common histologic subtype of invasive cervical carcinoma?
- Squamous cell carcinoma.
- Which HPV oncoprotein degrades the p53 tumor suppressor?
- E6.
- Which HPV oncoprotein inactivates the Rb tumor suppressor?
- E7.
- Where on the cervix does dysplasia most commonly arise?
- The transformation zone (squamocolumnar junction).
- What screening test detects cervical dysplasia before it becomes invasive cancer?
- The Pap smear (cervical cytology).
- What is the most common category of malignant ovarian tumor?
- Epithelial tumors, most often serous cystadenocarcinoma.
- What tumor marker is used to monitor epithelial ovarian carcinoma?
- CA-125.
- What is the most common benign germ cell tumor of the ovary?
- Mature cystic teratoma (dermoid cyst).
- What malignant ovarian germ cell tumor is histologically identical to testicular seminoma?
- Dysgerminoma.