Gynecologic and testicular tumor classification, cervical dysplasia grading, and placental pathology, one finding per card. Original cards testing the underlying concepts.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- Which two HPV genotypes carry the highest risk for cervical cancer?
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HPV 16 and 18.- Which two HPV genotypes most commonly cause condyloma acuminatum (genital warts)?
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HPV 6 and 11.- What cytologic finding on Pap smear is the hallmark of HPV-infected squamous cells?
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Koilocytes (cells with perinuclear halos and irregular, raisinoid nuclei).- In CIN I, what fraction of the epithelial thickness shows dysplastic cells?
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The lower third of the epithelium.- In CIN II, what fraction of the epithelial thickness shows dysplastic cells?
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The lower two-thirds of the epithelium.- In CIN III, what fraction of the epithelial thickness shows dysplastic cells?
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The full thickness of the epithelium (carcinoma in situ).- What is the most common histologic subtype of invasive cervical carcinoma?
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Squamous cell carcinoma.- Which HPV oncoprotein degrades the p53 tumor suppressor?
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E6.- Which HPV oncoprotein inactivates the Rb tumor suppressor?
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E7.- Where on the cervix does dysplasia most commonly arise?
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The transformation zone (squamocolumnar junction).- What screening test detects cervical dysplasia before it becomes invasive cancer?
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The Pap smear (cervical cytology).- What is the most common category of malignant ovarian tumor?
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Epithelial tumors, most often serous cystadenocarcinoma.- What tumor marker is used to monitor epithelial ovarian carcinoma?
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CA-125.- What is the most common benign germ cell tumor of the ovary?
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Mature cystic teratoma (dermoid cyst).- What malignant ovarian germ cell tumor is histologically identical to testicular seminoma?
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Dysgerminoma.
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