Classic pediatric tumor morphology (Wilms tumor, neuroblastoma, retinoblastoma) distinct from the congenital-anomaly focus of the Embryology decks.
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- What is another name for Wilms tumor?
- Nephroblastoma
- What is the most common renal malignancy of childhood?
- Wilms tumor (nephroblastoma)
- What is the peak age of onset for Wilms tumor?
- 2 to 5 years old
- What embryologic tissue does Wilms tumor arise from?
- Metanephric blastema (nephrogenic blastema)
- What are the three classic histologic components of Wilms tumor?
- Blastemal, stromal, and epithelial components (triphasic)
- Mutation of which gene, located on chromosome 11p13, causes Wilms tumor?
- WT1
- What does the acronym WAGR syndrome stand for?
- Wilms tumor, Aniridia, Genitourinary anomalies, mental Retardation
- What is the classic triad of Denys-Drash syndrome?
- Nephropathy, Wilms tumor, and male pseudohermaphroditism
- Which overgrowth syndrome, linked to chromosome 11p15, increases the risk of Wilms tumor?
- Beckwith-Wiedemann syndrome
- How does a Wilms tumor classically present on abdominal exam?
- A large, unilateral abdominal or flank mass that does not cross the midline
- What histologic feature of Wilms tumor indicates an unfavorable prognosis?
- Anaplasia
- What is the most common extracranial solid tumor of childhood?
- Neuroblastoma
- What is the most common malignant tumor diagnosed in infants under 1 year old?
- Neuroblastoma
- What embryologic cell type gives rise to neuroblastoma?
- Neural crest cells
- What is the most common primary site of neuroblastoma?
- Adrenal medulla