Classic pediatric tumor morphology (Wilms tumor, neuroblastoma, retinoblastoma) distinct from the congenital-anomaly focus of the Embryology decks.
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- What is another name for Wilms tumor?
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Nephroblastoma- What is the most common renal malignancy of childhood?
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Wilms tumor (nephroblastoma)- What is the peak age of onset for Wilms tumor?
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2 to 5 years old- What embryologic tissue does Wilms tumor arise from?
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Metanephric blastema (nephrogenic blastema)- What are the three classic histologic components of Wilms tumor?
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Blastemal, stromal, and epithelial components (triphasic)- Mutation of which gene, located on chromosome 11p13, causes Wilms tumor?
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WT1- What does the acronym WAGR syndrome stand for?
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Wilms tumor, Aniridia, Genitourinary anomalies, mental Retardation- What is the classic triad of Denys-Drash syndrome?
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Nephropathy, Wilms tumor, and male pseudohermaphroditism- Which overgrowth syndrome, linked to chromosome 11p15, increases the risk of Wilms tumor?
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Beckwith-Wiedemann syndrome- How does a Wilms tumor classically present on abdominal exam?
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A large, unilateral abdominal or flank mass that does not cross the midline- What histologic feature of Wilms tumor indicates an unfavorable prognosis?
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Anaplasia- What is the most common extracranial solid tumor of childhood?
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Neuroblastoma- What is the most common malignant tumor diagnosed in infants under 1 year old?
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Neuroblastoma- What embryologic cell type gives rise to neuroblastoma?
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Neural crest cells- What is the most common primary site of neuroblastoma?
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Adrenal medulla
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