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Reproductive Medicine · USMLE Step 1

USMLE Reproductive: Sexually Transmitted Infections

Common sexually transmitted infections with their causative organism, hallmark presentation, and first-line treatment tested on USMLE Step 1.

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What is the Gram stain morphology of Neisseria gonorrhoeae?
Gram-negative diplococci
What type of discharge is classic for gonorrhea?
Purulent, thick, yellow-green discharge
First-line treatment for gonorrhea?
Ceftriaxone (intramuscular)
What is notable about the typical presentation of Chlamydia trachomatis infection?
Often asymptomatic, especially in women
First-line treatment for Chlamydia trachomatis infection?
Doxycycline
Which Chlamydia trachomatis serovars cause lymphogranuloma venereum?
L1, L2, and L3
What is the classic clinical progression of lymphogranuloma venereum?
A small painless genital ulcer followed by painful, matted inguinal lymphadenopathy (buboes)
Treponema pallidum
Syphilis
What is the hallmark lesion of primary syphilis?
A painless genital chancre
What is the classic rash distribution in secondary syphilis?
A maculopapular rash involving the palms and soles
What are condylomata lata?
Flat, wart-like lesions seen in secondary syphilis
What are gummas?
Granulomatous lesions seen in tertiary syphilis
What neurologic complication of tertiary syphilis affects the dorsal columns of the spinal cord?
Tabes dorsalis
What cardiovascular complication is associated with tertiary syphilis?
Syphilitic aortitis, which can cause a thoracic aortic aneurysm
Name the nontreponemal screening tests for syphilis.
VDRL and RPR

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