Hemophilia, von Willebrand disease, disseminated intravascular coagulation, and platelet disorders with their distinguishing lab findings.
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- Which clotting factor is deficient in Hemophilia A?
- Factor VIII
- Which clotting factor is deficient in Hemophilia B?
- Factor IX
- What is the inheritance pattern of Hemophilia A and B?
- X-linked recessive
- How does hemophilia affect the PTT (partial thromboplastin time)?
- PTT is prolonged
- How does hemophilia affect the PT (prothrombin time)?
- PT is normal
- How does hemophilia affect bleeding time?
- Bleeding time is normal
- What is the classic bleeding pattern seen in hemophilia?
- Hemarthroses (bleeding into joints) and deep muscle or soft tissue bleeds
- What is the mainstay treatment for hemophilia A and B?
- Replacement of the deficient clotting factor with recombinant factor concentrate
- What is the inheritance pattern of von Willebrand disease?
- Autosomal dominant
- What is the most common inherited bleeding disorder?
- Von Willebrand disease
- How does von Willebrand factor (vWF) help platelets adhere to an injured vessel wall?
- It mediates platelet adhesion to exposed subendothelial collagen
- Besides mediating platelet adhesion, which clotting factor does vWF stabilize in the blood?
- Factor VIII
- How does von Willebrand disease affect bleeding time?
- Bleeding time is prolonged
- How does von Willebrand disease typically affect PTT?
- Normal or mildly prolonged, due to low factor VIII levels
- How does von Willebrand disease affect platelet count?
- Platelet count is normal