Hemophilia, von Willebrand disease, disseminated intravascular coagulation, and platelet disorders with their distinguishing lab findings.
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- Which clotting factor is deficient in Hemophilia A?
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Factor VIII- Which clotting factor is deficient in Hemophilia B?
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Factor IX- What is the inheritance pattern of Hemophilia A and B?
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X-linked recessive- How does hemophilia affect the PTT (partial thromboplastin time)?
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PTT is prolonged- How does hemophilia affect the PT (prothrombin time)?
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PT is normal- How does hemophilia affect bleeding time?
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Bleeding time is normal- What is the classic bleeding pattern seen in hemophilia?
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Hemarthroses (bleeding into joints) and deep muscle or soft tissue bleeds- What is the mainstay treatment for hemophilia A and B?
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Replacement of the deficient clotting factor with recombinant factor concentrate- What is the inheritance pattern of von Willebrand disease?
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Autosomal dominant- What is the most common inherited bleeding disorder?
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Von Willebrand disease- How does von Willebrand factor (vWF) help platelets adhere to an injured vessel wall?
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It mediates platelet adhesion to exposed subendothelial collagen- Besides mediating platelet adhesion, which clotting factor does vWF stabilize in the blood?
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Factor VIII- How does von Willebrand disease affect bleeding time?
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Bleeding time is prolonged- How does von Willebrand disease typically affect PTT?
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Normal or mildly prolonged, due to low factor VIII levels- How does von Willebrand disease affect platelet count?
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Platelet count is normal
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