Male and female reproductive tract anatomy and embryologic development, including congenital anomalies, tested on USMLE Step 1.
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- The mesonephric (Wolffian) duct gives rise to male internal genitalia under the influence of
- Testosterone
- The paramesonephric (Mullerian) duct gives rise to female internal genitalia in the
- Absence of Mullerian-inhibiting substance
- Mullerian-inhibiting substance (anti-Mullerian hormone) is secreted by
- Sertoli cells in the developing testis
- The Wolffian duct develops into the
- Epididymis, vas deferens, and seminal vesicles
- The Mullerian duct develops into the
- Fallopian tubes, uterus, and upper portion of the vagina
- Persistent Mullerian duct syndrome results from
- A deficiency of or insensitivity to Mullerian-inhibiting substance in a genetic male
- A bicornuate uterus results from
- Incomplete fusion of the two Mullerian ducts
- The genital tubercle in the male develops into the
- Glans penis
- The genital tubercle in the female develops into the
- Clitoris
- The labioscrotal swellings in the male fuse to form the
- Scrotum
- The labioscrotal swellings in the female remain unfused to form the
- Labia majora
- Hypospadias results from
- Incomplete fusion of the urethral folds, causing the urethral opening to be on the ventral surface of the penis
- The ovaries develop primarily from the
- Genital ridge and primordial germ cells that migrate from the yolk sac
- The gubernaculum in the male guides
- Testicular descent into the scrotum
- Cryptorchidism refers to
- Failure of one or both testes to descend into the scrotum