A condensed rapid review pass over the highest yield hematology and oncology facts for final week review.
40 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common cause of microcytic anemia worldwide?
- Iron deficiency anemia
- In iron deficiency anemia, what happens to serum TIBC?
- It increases
- How does serum ferritin differ between iron deficiency anemia and anemia of chronic disease?
- Ferritin is low in iron deficiency anemia but normal or high in anemia of chronic disease
- What red blood cell shape is characteristic of thalassemia on peripheral smear?
- Target cells
- Vitamin B12 deficiency classically produces ____ on peripheral blood smear.
- hypersegmented neutrophils
- Which vitamin deficiency, B12 or folate, causes neurologic symptoms such as subacute combined degeneration?
- Vitamin B12 deficiency
- Why does G6PD deficiency cause hemolysis after oxidative stress such as sulfa drugs or fava beans?
- Red cells cannot regenerate enough NADPH to neutralize oxidative damage, so hemoglobin denatures and cells hemolyze
- What is the definitive treatment for hereditary spherocytosis?
- Splenectomy
- What amino acid substitution causes sickle cell disease?
- Glutamic acid is replaced by valine in the beta globin chain
- What infection does sickle cell trait provide partial protection against?
- Malaria
- Paroxysmal nocturnal hemoglobinuria results from a somatic mutation in which gene?
- PIGA
- Warm autoimmune hemolytic anemia is mediated by which antibody class?
- IgG
- Cold agglutinin disease is most often mediated by which antibody class?
- IgM
- What bone marrow finding defines aplastic anemia?
- A hypocellular marrow with fatty replacement
- What mutation is present in most cases of polycythemia vera?
- JAK2 V617F