A condensed rapid review pass over the highest yield hematology and oncology facts for final week review.
About this set
40 mixed cards for USMLE Step 1 Hematology and Oncology. It opens with "What is the most common cause of microcytic anemia worldwide?" and "In iron deficiency anemia, what happens to serum TIBC?". Study it alongside the other USMLE Step 1 sets below.
40 cards · mixed cards · AI-written, checked twice. Edit anything.
- What is the most common cause of microcytic anemia worldwide?
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Iron deficiency anemia- In iron deficiency anemia, what happens to serum TIBC?
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It increases- How does serum ferritin differ between iron deficiency anemia and anemia of chronic disease?
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Ferritin is low in iron deficiency anemia but normal or high in anemia of chronic disease- What red blood cell shape is characteristic of thalassemia on peripheral smear?
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Target cells- Vitamin B12 deficiency classically produces ____ on peripheral blood smear.
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hypersegmented neutrophils- Which vitamin deficiency, B12 or folate, causes neurologic symptoms such as subacute combined degeneration?
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Vitamin B12 deficiency- Why does G6PD deficiency cause hemolysis after oxidative stress such as sulfa drugs or fava beans?
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Red cells cannot regenerate enough NADPH to neutralize oxidative damage, so hemoglobin denatures and cells hemolyze- What is the definitive treatment for hereditary spherocytosis?
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Splenectomy- What amino acid substitution causes sickle cell disease?
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Glutamic acid is replaced by valine in the beta globin chain- What infection does sickle cell trait provide partial protection against?
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Malaria- Paroxysmal nocturnal hemoglobinuria results from a somatic mutation in which gene?
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PIGA- Warm autoimmune hemolytic anemia is mediated by which antibody class?
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IgG- Cold agglutinin disease is most often mediated by which antibody class?
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IgM- What bone marrow finding defines aplastic anemia?
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A hypocellular marrow with fatty replacement- What mutation is present in most cases of polycythemia vera?
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JAK2 V617F
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