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Embryology · USMLE Step 1

USMLE Embryology High-Yield Rapid Review

A condensed rapid review pass over the highest yield embryology facts for final week review.

40 cards · basic cards · AI-written, checked twice. Edit anything.

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Which germ layer forms the epidermis, CNS, and PNS?
Ectoderm
Which germ layer forms the GI tract lining and respiratory epithelium?
Endoderm
Which germ layer forms muscle, bone, and the cardiovascular system?
Mesoderm
The ____ induces the overlying ectoderm to form the neural plate.
notochord
What does the notochord become in the adult intervertebral disc?
Nucleus pulposus
Neural tube defects are most strongly linked to a deficiency of which vitamin?
Folate (vitamin B9)
Failure of the rostral neuropore to close causes which condition?
Anencephaly
Failure of the caudal neuropore to close causes which condition?
Spina bifida
An elevated maternal serum AFP most commonly suggests which type of fetal defect?
A neural tube defect (e.g., spina bifida)
A decreased maternal serum AFP is classically associated with which condition?
Down syndrome (trisomy 21)
Neural crest cells give rise to which pigment-producing skin cell?
Melanocytes
Neural crest cells give rise to which adrenal gland region?
Adrenal medulla (chromaffin cells)
What gene on the Y chromosome triggers development of testes from the bipotential gonad?
SRY gene
Which fetal duct system develops into the epididymis, vas deferens, and seminal vesicles?
Mesonephric (Wolffian) duct
Which fetal duct system develops into the uterus, fallopian tubes, and upper vagina?
Paramesonephric (Mullerian) duct

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