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Reproductive Medicine · USMLE Step 1 · Healthcare and Nursing

USMLE Reproductive: Pregnancy and Obstetric Complications

Preeclampsia, gestational diabetes, ectopic pregnancy, and placental abruption concepts tested on USMLE Step 1, beyond the endocrinology and pathology overview.

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35 basic cards for USMLE Step 1 Reproductive Medicine. Set 6 of 8 in USMLE Reproductive. It opens with "What blood pressure reading, confirmed on two occasions, defines hypertension" and "What urine protein level over 24 hours is a diagnostic criterion for". Study it alongside the other USMLE Step 1 sets below.

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What blood pressure reading, confirmed on two occasions, defines hypertension in preeclampsia after 20 weeks gestation?
Show answer140/90 mmHg or higher
What urine protein level over 24 hours is a diagnostic criterion for preeclampsia?
Show answer300 mg or more per 24 hours
What early placental defect underlies the pathophysiology of preeclampsia?
Show answerFailure of trophoblastic remodeling of the spiral arteries, causing placental ischemia
In preeclampsia, is maternal serum sFlt-1 (soluble fms-like tyrosine kinase-1) increased or decreased?
Show answerIncreased
In preeclampsia, is maternal serum placental growth factor (PlGF) increased or decreased?
Show answerDecreased
HELLP syndrome, a severe complication of preeclampsia, stands for Hemolysis, Elevated Liver enzymes, and ____.
Show answerLow Platelets
What clinical event defines eclampsia in a patient with preeclampsia?
Show answerNew-onset generalized tonic-clonic seizures
What drug is given to prevent and treat seizures in severe preeclampsia and eclampsia?
Show answerMagnesium sulfate
What is the only definitive treatment for preeclampsia?
Show answerDelivery of the fetus and placenta
At what point in pregnancy is universal screening for gestational diabetes typically performed?
Show answer24 to 28 weeks gestation
What initial screening test is used for gestational diabetes?
Show answer1-hour 50-gram oral glucose challenge test
What placental hormone is a major cause of maternal insulin resistance during pregnancy?
Show answerHuman placental lactogen (hPL)
What is the first-line treatment for gestational diabetes?
Show answerDiet and exercise (lifestyle modification)
Poorly controlled gestational diabetes causes fetal hyperinsulinemia, which leads to what fetal growth complication?
Show answerMacrosomia
Why do infants of diabetic mothers often develop hypoglycemia shortly after birth?
Show answerFetal hyperinsulinemia persists after the maternal glucose supply is cut off at delivery

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