Cholinergic, adrenergic, and autonomic blocking drugs with receptor target and one signature clinical effect per card.
38 cards · basic cards · AI-written, checked twice. Edit anything.
- Bethanechol: receptor target and main clinical use?
- Muscarinic receptor agonist; used for postoperative/neurogenic ileus and urinary retention
- Pilocarpine: receptor target and main clinical use?
- Muscarinic receptor agonist; used to treat open-angle glaucoma and xerostomia
- Methacholine, a muscarinic receptor agonist, is used in a bronchial challenge test to help diagnose ____.
- asthma
- Carbachol: receptor target and main clinical use?
- Muscarinic and nicotinic receptor agonist; produces miosis in glaucoma and eye surgery
- Nicotine: receptor target?
- Nicotinic acetylcholine receptor agonist at autonomic ganglia and the neuromuscular junction
- Physostigmine: mechanism and signature clinical use?
- Acetylcholinesterase inhibitor that crosses the blood brain barrier; antidote for anticholinergic (atropine) toxicity
- Neostigmine: mechanism and signature clinical use?
- Acetylcholinesterase inhibitor that does not cross the blood brain barrier; used for postoperative ileus, urinary retention, and reversal of neuromuscular blockade
- Pyridostigmine: mechanism and signature clinical use?
- Acetylcholinesterase inhibitor; used for long-term maintenance treatment of myasthenia gravis
- The historic Tensilon test used the short-acting acetylcholinesterase inhibitor ____ to help diagnose myasthenia gravis.
- edrophonium
- Donepezil: mechanism and signature clinical use?
- Acetylcholinesterase inhibitor; used to treat Alzheimer disease
- Organophosphate poisoning irreversibly inhibits acetylcholinesterase, producing a cholinergic toxidrome treated with atropine plus ____.
- pralidoxime
- Pralidoxime: mechanism of action in organophosphate poisoning?
- Regenerates acetylcholinesterase by cleaving the phosphate bond, most effective before enzyme aging occurs
- Atropine used as a toxicology antidote: receptor target and indication?
- Muscarinic receptor antagonist; antidote for cholinergic toxicity such as organophosphate poisoning
- Atropine used to treat symptomatic bradycardia: receptor target?
- Muscarinic receptor antagonist (blocks vagal tone on the SA node)
- Benztropine: receptor target and clinical use?
- Muscarinic receptor antagonist; treats Parkinson disease symptoms and antipsychotic-induced extrapyramidal side effects