Immunosuppressant and chemotherapy drug classes with mechanism of action and one signature toxicity per card.
41 cards · mixed cards · AI-written, checked twice. Edit anything.
- Cyclosporine: mechanism of action
Show answer
Binds cyclophilin, inhibiting calcineurin and blocking IL-2 gene transcription- Signature toxicity of cyclosporine
Show answer
Nephrotoxicity- Tacrolimus: mechanism of action
Show answer
Binds FKBP, inhibiting calcineurin and blocking IL-2 transcription- Sirolimus (rapamycin): mechanism of action
Show answer
Binds FKBP and inhibits mTOR, blocking the cellular response to IL-2- Unlike cyclosporine and tacrolimus, sirolimus causes ____ rather than nephrotoxicity.
Show answer
pancytopenia and hyperlipidemia- Azathioprine: mechanism of action
Show answer
A purine analog (prodrug of 6-mercaptopurine) that inhibits de novo purine synthesis, suppressing lymphocyte proliferation- Signature toxicity of azathioprine
Show answer
Bone marrow suppression- Mycophenolate mofetil: mechanism of action
Show answer
Inhibits inosine monophosphate dehydrogenase, blocking purine synthesis selectively in B and T lymphocytes- Basiliximab: mechanism of action
Show answer
Monoclonal antibody that blocks the IL-2 receptor (CD25) on activated T cells- Signature toxicity of basiliximab
Show answer
Hypersensitivity reactions and edema- Cyclophosphamide: mechanism of action
Show answer
Alkylates and cross-links DNA at guanine N7, requiring hepatic activation to its active form- Signature toxicity of cyclophosphamide
Show answer
Hemorrhagic cystitis, caused by the metabolite acrolein- Cisplatin: mechanism of action
Show answer
Cross-links DNA, triggering apoptosis in a cell cycle nonspecific manner- Cisplatin's dose-limiting toxicities are ____.
Show answer
nephrotoxicity and ototoxicity- Methotrexate: mechanism of action
Show answer
Inhibits dihydrofolate reductase, blocking regeneration of tetrahydrofolate and halting DNA synthesis
FlashKeepers