Immunosuppressant and chemotherapy drug classes with mechanism of action and one signature toxicity per card.
41 cards · basic cards · AI-written, checked twice. Edit anything.
- Cyclosporine: mechanism of action
- Binds cyclophilin, inhibiting calcineurin and blocking IL-2 gene transcription
- Signature toxicity of cyclosporine
- Nephrotoxicity
- Tacrolimus: mechanism of action
- Binds FKBP, inhibiting calcineurin and blocking IL-2 transcription
- Sirolimus (rapamycin): mechanism of action
- Binds FKBP and inhibits mTOR, blocking the cellular response to IL-2
- Unlike cyclosporine and tacrolimus, sirolimus causes ____ rather than nephrotoxicity.
- pancytopenia and hyperlipidemia
- Azathioprine: mechanism of action
- A purine analog (prodrug of 6-mercaptopurine) that inhibits de novo purine synthesis, suppressing lymphocyte proliferation
- Signature toxicity of azathioprine
- Bone marrow suppression
- Mycophenolate mofetil: mechanism of action
- Inhibits inosine monophosphate dehydrogenase, blocking purine synthesis selectively in B and T lymphocytes
- Basiliximab: mechanism of action
- Monoclonal antibody that blocks the IL-2 receptor (CD25) on activated T cells
- Signature toxicity of basiliximab
- Hypersensitivity reactions and edema
- Cyclophosphamide: mechanism of action
- Alkylates and cross-links DNA at guanine N7, requiring hepatic activation to its active form
- Signature toxicity of cyclophosphamide
- Hemorrhagic cystitis, caused by the metabolite acrolein
- Cisplatin: mechanism of action
- Cross-links DNA, triggering apoptosis in a cell cycle nonspecific manner
- Cisplatin's dose-limiting toxicities are ____.
- nephrotoxicity and ototoxicity
- Methotrexate: mechanism of action
- Inhibits dihydrofolate reductase, blocking regeneration of tetrahydrofolate and halting DNA synthesis