NSAIDs, DMARDs, and gout medications with mechanism of action and one signature side effect per card.
38 cards · basic cards · AI-written, checked twice. Edit anything.
- Aspirin irreversibly inhibits ____ enzymes by acetylation, blocking prostaglandin and thromboxane synthesis.
- cyclooxygenase (COX)
- What serious pediatric syndrome is linked to aspirin use during a viral illness?
- Reye syndrome (hepatic failure and encephalopathy)
- What is the mechanism of action of ibuprofen?
- Reversible, nonselective inhibition of COX-1 and COX-2
- Ibuprofen can rarely cause what CNS complication, especially in patients with lupus?
- Aseptic meningitis
- What is the mechanism of action of naproxen?
- Nonselective, reversible inhibition of COX-1 and COX-2
- What is a signature adverse effect of naproxen, like other NSAIDs?
- Gastric ulceration and GI bleeding
- What is the mechanism of action of indomethacin?
- Nonselective COX-1/COX-2 inhibition (potent NSAID)
- Indomethacin is notorious among NSAIDs for causing which class of adverse effects most severely?
- Severe GI toxicity (ulceration and bleeding)
- What is the mechanism of action of ketorolac?
- Potent, nonselective COX-1/COX-2 inhibition
- What signature adverse effect limits ketorolac use to 5 days or less?
- Acute kidney injury (nephrotoxicity)
- What is the mechanism of action of celecoxib?
- Selective inhibition of COX-2, sparing COX-1 and platelet thromboxane A2
- Celecoxib carries an increased risk of ____ due to selective COX-2 inhibition.
- myocardial infarction and stroke
- What is the mechanism of action of diclofenac?
- Nonselective inhibition of COX-1 and COX-2
- Diclofenac has the highest risk among NSAIDs of causing what organ toxicity?
- Hepatotoxicity (elevated liver enzymes)
- What is the mechanism of action of acetaminophen?
- Inhibits COX mainly in the central nervous system, with minimal peripheral anti-inflammatory effect