NSAIDs, DMARDs, and gout medications with mechanism of action and one signature side effect per card.
About this set
38 mixed cards for USMLE Step 1 Pharmacology. Set 13 of 19 in USMLE Pharmacology. It opens with "Aspirin irreversibly inhibits ____ enzymes by acetylation, blocking" and "What serious pediatric syndrome is linked to aspirin use during a viral illness?". Study it alongside the other USMLE Step 1 sets below.
38 cards · mixed cards · AI-written, checked twice. Edit anything.
- Aspirin irreversibly inhibits ____ enzymes by acetylation, blocking prostaglandin and thromboxane synthesis.
Show answer
cyclooxygenase (COX)- What serious pediatric syndrome is linked to aspirin use during a viral illness?
Show answer
Reye syndrome (hepatic failure and encephalopathy)- What is the mechanism of action of ibuprofen?
Show answer
Reversible, nonselective inhibition of COX-1 and COX-2- Ibuprofen can rarely cause what CNS complication, especially in patients with lupus?
Show answer
Aseptic meningitis- What is the mechanism of action of naproxen?
Show answer
Nonselective, reversible inhibition of COX-1 and COX-2- What is a signature adverse effect of naproxen, like other NSAIDs?
Show answer
Gastric ulceration and GI bleeding- What is the mechanism of action of indomethacin?
Show answer
Nonselective COX-1/COX-2 inhibition (potent NSAID)- Indomethacin is notorious among NSAIDs for causing which class of adverse effects most severely?
Show answer
Severe GI toxicity (ulceration and bleeding)- What is the mechanism of action of ketorolac?
Show answer
Potent, nonselective COX-1/COX-2 inhibition- What signature adverse effect limits ketorolac use to 5 days or less?
Show answer
Acute kidney injury (nephrotoxicity)- What is the mechanism of action of celecoxib?
Show answer
Selective inhibition of COX-2, sparing COX-1 and platelet thromboxane A2- Celecoxib carries an increased risk of ____ due to selective COX-2 inhibition.
Show answer
myocardial infarction and stroke- What is the mechanism of action of diclofenac?
Show answer
Nonselective inhibition of COX-1 and COX-2- Diclofenac has the highest risk among NSAIDs of causing what organ toxicity?
Show answer
Hepatotoxicity (elevated liver enzymes)- What is the mechanism of action of acetaminophen?
Show answer
Inhibits COX mainly in the central nervous system, with minimal peripheral anti-inflammatory effect
FlashKeepers