Breast pathology morphology including fibroadenoma, ductal carcinoma in situ, and invasive carcinoma subtypes, one finding per card.
32 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common benign breast tumor in women under 30?
- Fibroadenoma
- On exam, a fibroadenoma classically feels like what kind of mass?
- A well-circumscribed, mobile, rubbery mass (sometimes called a breast mouse)
- Phyllodes tumors typically occur in which age group, compared to fibroadenomas?
- Older women, typically in their 40s to 60s
- What histologic pattern is characteristic of a phyllodes tumor?
- Leaf-like fronds with stromal overgrowth
- Unlike fibroadenoma, a phyllodes tumor can behave in what way?
- It can be malignant
- What is the classic presenting symptom of an intraductal papilloma?
- Bloody or serous nipple discharge
- What is the histologic finding in intraductal papilloma?
- A papillary growth within a single dilated duct
- What history is classically associated with fat necrosis of the breast?
- Trauma to the breast
- Why is fat necrosis clinically important despite being benign?
- It can mimic carcinoma on exam and imaging
- What is the histologic appearance of fat necrosis?
- Necrotic fat with lipid-laden macrophages and saponification
- Fibrocystic change is the most common cause of a breast lump in which age group?
- Premenopausal women aged 20 to 40
- Which subtype of fibrocystic change actually increases breast cancer risk?
- Atypical hyperplasia
- What defines ductal carcinoma in situ (DCIS)?
- Malignant epithelial cells confined within the duct, with an intact basement membrane
- Which DCIS subtype shows central necrosis and is linked to calcifications on mammography?
- Comedocarcinoma
- What molecular change is the hallmark of lobular carcinoma in situ (LCIS)?
- Loss of E-cadherin expression