A condensed rapid review pass over the highest yield hematology, oncology, and musculoskeletal facts for final week review.
40 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the classic lab pattern in iron deficiency anemia?
- Low ferritin and high TIBC, with low serum iron.
- What is the classic lab pattern in anemia of chronic disease?
- Low serum iron, low TIBC, and high ferritin.
- In vitamin B12 deficiency, the blood smear classically shows ____.
- hypersegmented neutrophils
- What neurologic complication is unique to B12 deficiency and not seen in folate deficiency?
- Subacute combined degeneration of the dorsal columns and corticospinal tracts.
- What is the molecular defect in most cases of hereditary spherocytosis?
- Deficiency of spectrin or ankyrin in the red cell membrane cytoskeleton.
- What is the definitive treatment for symptomatic hereditary spherocytosis?
- Splenectomy.
- What red cell findings appear on smear during a G6PD deficiency hemolytic episode?
- Heinz bodies and bite cells.
- What point mutation causes sickle cell disease?
- A single amino acid substitution of valine for glutamic acid at position 6 of the beta globin chain.
- Which hemoglobin is markedly elevated in beta thalassemia major?
- Hemoglobin F (fetal hemoglobin).
- What antibody class mediates warm autoimmune hemolytic anemia?
- IgG.
- What antibody class mediates cold autoimmune hemolytic anemia?
- IgM.
- What lab pattern characterizes disseminated intravascular coagulation?
- Schistocytes on smear, low platelets, low fibrinogen, elevated D-dimer, and prolonged PT/PTT.
- What enzyme is deficient in thrombotic thrombocytopenic purpura?
- ADAMTS13, a von Willebrand factor cleaving protease.
- What is the underlying mechanism of immune thrombocytopenic purpura?
- Autoantibodies against platelet surface proteins cause splenic platelet destruction.
- Which clotting factor is deficient in hemophilia A?
- Factor VIII.