A condensed rapid review pass over the highest yield hematology, oncology, and musculoskeletal facts for final week review.
40 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the classic lab pattern in iron deficiency anemia?
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Low ferritin and high TIBC, with low serum iron.- What is the classic lab pattern in anemia of chronic disease?
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Low serum iron, low TIBC, and high ferritin.- In vitamin B12 deficiency, the blood smear classically shows ____.
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hypersegmented neutrophils- What neurologic complication is unique to B12 deficiency and not seen in folate deficiency?
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Subacute combined degeneration of the dorsal columns and corticospinal tracts.- What is the molecular defect in most cases of hereditary spherocytosis?
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Deficiency of spectrin or ankyrin in the red cell membrane cytoskeleton.- What is the definitive treatment for symptomatic hereditary spherocytosis?
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Splenectomy.- What red cell findings appear on smear during a G6PD deficiency hemolytic episode?
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Heinz bodies and bite cells.- What point mutation causes sickle cell disease?
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A single amino acid substitution of valine for glutamic acid at position 6 of the beta globin chain.- Which hemoglobin is markedly elevated in beta thalassemia major?
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Hemoglobin F (fetal hemoglobin).- What antibody class mediates warm autoimmune hemolytic anemia?
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IgG.- What antibody class mediates cold autoimmune hemolytic anemia?
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IgM.- What lab pattern characterizes disseminated intravascular coagulation?
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Schistocytes on smear, low platelets, low fibrinogen, elevated D-dimer, and prolonged PT/PTT.- What enzyme is deficient in thrombotic thrombocytopenic purpura?
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ADAMTS13, a von Willebrand factor cleaving protease.- What is the underlying mechanism of immune thrombocytopenic purpura?
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Autoantibodies against platelet surface proteins cause splenic platelet destruction.- Which clotting factor is deficient in hemophilia A?
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Factor VIII.
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