Transplant rejection types and graft-versus-host disease morphology, one finding per card.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the timing of hyperacute transplant rejection after revascularization?
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Minutes to hours- What causes hyperacute rejection?
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Preformed antidonor antibodies already present in the recipient- What type of hypersensitivity reaction is hyperacute rejection?
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Type II hypersensitivity- What happens when preformed antibodies bind donor endothelium in hyperacute rejection?
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Complement activation, causing endothelial damage- What is the characteristic finding in hyperacute rejection?
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Widespread thrombosis of graft vessels- Why does a hyperacutely rejected graft need to be removed?
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It never becomes vascularized and undergoes ischemic necrosis- What pretransplant test prevents hyperacute rejection?
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Crossmatch testing for preformed antidonor antibodies- What is the typical timing of acute transplant rejection?
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Weeks to months after transplant- What are the two mechanisms of acute transplant rejection?
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Cellular (T cell-mediated) and humoral (antibody-mediated)- Which immune cells mediate acute cellular rejection?
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CD8+ cytotoxic T cells- What do CD8+ T cells target in acute cellular rejection?
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Donor MHC antigens on graft cells- What histologic finding characterizes acute cellular rejection?
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Dense interstitial lymphocytic infiltrate- What is tubulitis, seen in acute cellular rejection of a kidney transplant?
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Lymphocytes invading and damaging the renal tubular epithelium- What vascular finding is seen in acute cellular rejection?
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Endothelialitis, lymphocytes beneath the vascular endothelium- What mediates acute humoral (antibody-mediated) rejection?
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Antidonor antibodies plus complement activation against graft vasculature
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