Pathology · USMLE Step 1

USMLE Pathology Terms

Classic pathology vocabulary and named signs/eponyms with a one-line definition each.

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Apoptosis
Programmed cell death characterized by cell shrinkage, membrane blebbing, and fragmentation without inflammatory response.
Necrosis
Pathological cell death caused by external injury, characterized by cell swelling, membrane rupture, and inflammation.
Autophagy
Cellular self-digestion through sequestration of cytoplasm and organelles in membrane-bound autophagosomes.
Hypertrophy
Increase in the size of individual cells, leading to enlarged organ or tissue mass.
Hyperplasia
Increase in the number of cells in an organ or tissue, usually due to increased demand or growth factor stimulation.
Atrophy
Decrease in cell size and tissue mass, often due to disuse, denervation, or decreased blood supply.
Metaplasia
Reversible replacement of one differentiated cell type with another mature cell type, usually in response to chronic irritation.
Dysplasia
Disorderly growth of cells characterized by nuclear enlargement, increased mitotic activity, and loss of normal tissue architecture.
Anaplasia
Loss of cellular differentiation in malignant tumors, with primitive appearance and high mitotic activity.
Steatosis
Abnormal accumulation of fat (triglycerides) within cells, most commonly seen in the liver.
Fibrosis
Excessive deposition of collagen in tissue, typically resulting from chronic inflammation or injury.
Cirrhosis
End-stage liver disease characterized by widespread fibrosis, regenerative nodules, and loss of normal liver architecture.
Granuloma
Collection of epithelioid macrophages and multinucleated giant cells, typically forming in response to persistent irritants or infections.
Abscess
Localized collection of pus (dead neutrophils, bacteria, and cellular debris) within tissue.
Exudate
Inflammatory fluid with high protein concentration (>2.5 g/dL) and many cells, indicating increased vascular permeability.

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