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Pathology · USMLE Step 1 · Healthcare and Nursing

USMLE Pathology Terms

Classic pathology vocabulary and named signs/eponyms with a one-line definition each.

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46 basic cards for USMLE Step 1 Pathology. It opens with "Apoptosis" and "Necrosis". Study it alongside the other USMLE Step 1 sets below.

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Apoptosis
Show answerProgrammed cell death characterized by cell shrinkage, membrane blebbing, and fragmentation without inflammatory response.
Necrosis
Show answerPathological cell death caused by external injury, characterized by cell swelling, membrane rupture, and inflammation.
Autophagy
Show answerCellular self-digestion through sequestration of cytoplasm and organelles in membrane-bound autophagosomes.
Hypertrophy
Show answerIncrease in the size of individual cells, leading to enlarged organ or tissue mass.
Hyperplasia
Show answerIncrease in the number of cells in an organ or tissue, usually due to increased demand or growth factor stimulation.
Atrophy
Show answerDecrease in cell size and tissue mass, often due to disuse, denervation, or decreased blood supply.
Metaplasia
Show answerReversible replacement of one differentiated cell type with another mature cell type, usually in response to chronic irritation.
Dysplasia
Show answerDisorderly growth of cells characterized by nuclear enlargement, increased mitotic activity, and loss of normal tissue architecture.
Anaplasia
Show answerLoss of cellular differentiation in malignant tumors, with primitive appearance and high mitotic activity.
Steatosis
Show answerAbnormal accumulation of fat (triglycerides) within cells, most commonly seen in the liver.
Fibrosis
Show answerExcessive deposition of collagen in tissue, typically resulting from chronic inflammation or injury.
Cirrhosis
Show answerEnd-stage liver disease characterized by widespread fibrosis, regenerative nodules, and loss of normal liver architecture.
Granuloma
Show answerCollection of epithelioid macrophages and multinucleated giant cells, typically forming in response to persistent irritants or infections.
Abscess
Show answerLocalized collection of pus (dead neutrophils, bacteria, and cellular debris) within tissue.
Exudate
Show answerInflammatory fluid with high protein concentration (>2.5 g/dL) and many cells, indicating increased vascular permeability.

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