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Pathology · USMLE Step 1 · Healthcare and Nursing

USMLE Pathology: Tumor Markers and Staging

Common serum tumor markers and TNM and grading staging systems used across organ systems, a cross-cutting oncology concept deck.

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34 basic cards for USMLE Step 1 Pathology. Set 26 of 27 in USMLE Pathology. It opens with "Which tumor marker is elevated in hepatocellular carcinoma?" and "Which tumor marker is elevated in yolk sac (endodermal sinus) tumors?". Study it alongside the other USMLE Step 1 sets below.

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Which tumor marker is elevated in hepatocellular carcinoma?
Show answerAlpha-fetoprotein (AFP)
Which tumor marker is elevated in yolk sac (endodermal sinus) tumors?
Show answerAlpha-fetoprotein (AFP)
Which tumor marker is used to monitor for recurrence of colorectal carcinoma?
Show answerCarcinoembryonic antigen (CEA)
Which tumor marker is associated with ovarian cancer?
Show answerCA-125
Which tumor marker is associated with pancreatic adenocarcinoma?
Show answerCA 19-9
Which tumor marker is used for prostate cancer, though it is also elevated in benign prostatic hyperplasia and prostatitis?
Show answerProstate-specific antigen (PSA)
Which tumor marker is characteristically elevated in choriocarcinoma?
Show answerBeta human chorionic gonadotropin (beta-hCG)
Besides choriocarcinoma, what other tumor type commonly elevates beta-hCG?
Show answerTesticular germ cell tumors
Which tumor marker is produced by parafollicular C cells and used to detect medullary thyroid carcinoma?
Show answerCalcitonin
Which serum marker is used to detect neuroendocrine tumors?
Show answerChromogranin A
Which immunohistochemical marker is characteristic of melanoma?
Show answerS-100
Besides melanoma, what other condition stains positive for S-100?
Show answerLangerhans cell histiocytosis
Which enzyme marker, tartrate-resistant acid phosphatase, is used to diagnose a leukemia with 'hairy' cells?
Show answerHairy cell leukemia
Which serum marker is elevated in osteosarcoma and Paget disease of bone?
Show answerAlkaline phosphatase
Which enzyme is used as a marker of tumor burden in seminoma and lymphoma rather than as a specific diagnostic marker?
Show answerLactate dehydrogenase (LDH)

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