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Pharmacology · USMLE Step 1

USMLE Pharmacology: Respiratory Drugs

Bronchodilators and leukotriene inhibitors with mechanism of action and one signature side effect per card, distinct from the clinical inhaler-technique focus of the Nursing Pharmacology respiratory deck.

40 cards · basic cards · AI-written, checked twice. Edit anything.

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What drug class does albuterol belong to?
Short-acting beta-2 agonist (SABA)
Mechanism of action of albuterol
Binds beta-2 adrenergic receptors, activating adenylyl cyclase to raise cAMP and relax bronchial smooth muscle
Signature side effect of albuterol
Tremor and tachycardia
Why can beta-2 agonists like albuterol cause hypokalemia?
They stimulate the Na+/K+-ATPase, driving potassium into cells
Levalbuterol is what relative to albuterol?
The R-enantiomer of albuterol
What drug class is salmeterol?
Long-acting beta-2 agonist (LABA)
Why is salmeterol not used to abort an acute asthma attack?
It has a slow onset of action
How does formoterol differ from salmeterol in onset?
Formoterol has a rapid onset of action despite being a LABA
Black box warning for LABAs used as monotherapy in asthma
Increased risk of asthma-related death without a concurrent inhaled corticosteroid
Off-label obstetric use of terbutaline
Tocolysis, to delay preterm labor
Beta-2 agonists relax bronchial smooth muscle by activating ____, which raises intracellular cAMP.
adenylyl cyclase
SABA
Short-acting beta-2 agonist
LABA
Long-acting beta-2 agonist
What drug class is ipratropium?
Short-acting muscarinic antagonist (SAMA)
Mechanism of action of ipratropium
Antagonizes M3 muscarinic receptors in bronchial smooth muscle, blocking acetylcholine-induced bronchoconstriction

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