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Pharmacology · USMLE Step 1 · Healthcare and Nursing

USMLE Pharmacology: Vaccines and Biologic Therapeutics

Monoclonal antibody and biologic DMARD drug classes with their mechanism and one signature side effect per card, distinct from the innate and adaptive immune cell focus of the Immunology decks.

About this set

35 basic cards for USMLE Step 1 Pharmacology. Set 19 of 19 in USMLE Pharmacology. It opens with "Infliximab: antibody class and target?" and "Signature adverse effect of infliximab?". Study it alongside the other USMLE Step 1 sets below.

35 cards · basic cards · AI-written, checked twice. Edit anything.

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Infliximab: antibody class and target?
Show answerChimeric monoclonal antibody against TNF-alpha
Signature adverse effect of infliximab?
Show answerReactivation of latent tuberculosis
How does etanercept differ structurally from other anti-TNF drugs?
Show answerIt is a fusion protein of the TNF receptor and IgG Fc region, not a true monoclonal antibody
Adalimumab: antibody class and target?
Show answerFully human monoclonal antibody against TNF-alpha
Signature neurologic risk of anti-TNF therapy as a drug class?
Show answerIncreased risk of demyelinating disease resembling multiple sclerosis
Rituximab mechanism of action?
Show answerMonoclonal antibody against CD20 that depletes B lymphocytes
Signature risk of rituximab therapy?
Show answerProgressive multifocal leukoencephalopathy from JC virus reactivation
Trastuzumab target?
Show answerHER2/neu receptor
Signature adverse effect of trastuzumab?
Show answerCardiotoxicity (reduced left ventricular ejection fraction)
Bevacizumab mechanism of action?
Show answerMonoclonal antibody against VEGF that inhibits angiogenesis
Signature adverse effect of bevacizumab?
Show answerGastrointestinal perforation
Cetuximab target?
Show answerEpidermal growth factor receptor (EGFR)
Signature adverse effect of cetuximab?
Show answerAcneiform (papulopustular) rash
Natalizumab mechanism of action?
Show answerMonoclonal antibody against alpha-4 integrin that blocks leukocyte migration across the blood brain barrier
Signature risk of natalizumab therapy?
Show answerProgressive multifocal leukoencephalopathy from JC virus reactivation

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