Contraceptives, SERMs, and hormone therapy drugs with mechanism of action, distinct from the diabetes and thyroid focus of the endocrine drugs deck.
38 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the primary mechanism by which combined oral contraceptives (COCs) prevent pregnancy?
- They suppress the LH surge, preventing ovulation.
- Which hormone component of combined oral contraceptives thickens cervical mucus to impede sperm?
- The progestin component.
- How do progestin-only pills prevent pregnancy?
- By thickening cervical mucus and thinning the endometrium.
- Leuprolide belongs to what drug class?
- GnRH agonist.
- What happens to gonadotropin release with continuous, non-pulsatile GnRH agonist therapy?
- GnRH receptors downregulate, suppressing LH and FSH release.
- What is the flare effect seen at the start of GnRH agonist therapy?
- A transient rise in testosterone or estrogen before sustained hormone suppression occurs.
- Leuprolide is used in the treatment of which cancer?
- Prostate cancer.
- Besides prostate cancer, leuprolide is used to treat which gynecologic condition?
- Endometriosis.
- Ganirelix and cetrorelix belong to what drug class?
- GnRH antagonists.
- What is the main clinical use of GnRH antagonists such as ganirelix?
- Preventing a premature LH surge during controlled ovarian stimulation for IVF.
- What is the mechanism of action of mifepristone?
- It is a progesterone receptor antagonist.
- What is the main clinical use of mifepristone?
- Medical abortion, given together with misoprostol.
- What role does misoprostol play in medical abortion regimens?
- As a prostaglandin E1 analog, it ripens the cervix and induces uterine contractions.
- What is the mechanism of action of ulipristal acetate?
- It is a selective progesterone receptor modulator.
- What is the main clinical use of ulipristal acetate?
- Emergency contraception.