Lung cancer histologic subtype classification and mediastinal tumor morphology, one finding per card.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common histologic subtype of lung cancer overall?
- Adenocarcinoma
- Where in the lung does adenocarcinoma typically arise?
- Peripherally
- Which immunohistochemical marker is characteristically positive in lung adenocarcinoma?
- TTF-1 (thyroid transcription factor 1)
- What growth pattern describes adenocarcinoma in situ spreading along intact alveolar septa without invasion?
- Lepidic growth pattern
- Which lung cancer subtype is most common in lifelong nonsmokers?
- Adenocarcinoma
- Where does squamous cell carcinoma of the lung typically arise?
- Centrally, near the hilum or major bronchi
- What two histologic features characterize squamous cell carcinoma of the lung?
- Keratin pearls and intercellular bridges
- What paraneoplastic syndrome is classically caused by squamous cell lung carcinoma secreting PTHrP?
- Hypercalcemia
- Which lung cancer subtype is most often associated with central cavitation?
- Squamous cell carcinoma
- Where does small cell (oat cell) carcinoma of the lung typically arise?
- Centrally, near the hilum
- From which cell type does small cell lung carcinoma arise?
- Neuroendocrine (Kulchitsky) cells
- What nuclear feature is classic on histology of small cell lung carcinoma?
- Salt and pepper chromatin in small cells with scant cytoplasm
- Which lung cancer subtype has the strongest association with cigarette smoking?
- Small cell carcinoma
- What paraneoplastic syndrome results from ectopic ADH secretion by small cell lung carcinoma?
- SIADH (syndrome of inappropriate antidiuretic hormone secretion)
- What paraneoplastic syndrome results from ectopic ACTH secretion by small cell lung carcinoma?
- Cushing syndrome