Lung cancer histologic subtype classification and mediastinal tumor morphology, one finding per card.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common histologic subtype of lung cancer overall?
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Adenocarcinoma- Where in the lung does adenocarcinoma typically arise?
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Peripherally- Which immunohistochemical marker is characteristically positive in lung adenocarcinoma?
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TTF-1 (thyroid transcription factor 1)- What growth pattern describes adenocarcinoma in situ spreading along intact alveolar septa without invasion?
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Lepidic growth pattern- Which lung cancer subtype is most common in lifelong nonsmokers?
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Adenocarcinoma- Where does squamous cell carcinoma of the lung typically arise?
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Centrally, near the hilum or major bronchi- What two histologic features characterize squamous cell carcinoma of the lung?
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Keratin pearls and intercellular bridges- What paraneoplastic syndrome is classically caused by squamous cell lung carcinoma secreting PTHrP?
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Hypercalcemia- Which lung cancer subtype is most often associated with central cavitation?
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Squamous cell carcinoma- Where does small cell (oat cell) carcinoma of the lung typically arise?
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Centrally, near the hilum- From which cell type does small cell lung carcinoma arise?
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Neuroendocrine (Kulchitsky) cells- What nuclear feature is classic on histology of small cell lung carcinoma?
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Salt and pepper chromatin in small cells with scant cytoplasm- Which lung cancer subtype has the strongest association with cigarette smoking?
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Small cell carcinoma- What paraneoplastic syndrome results from ectopic ADH secretion by small cell lung carcinoma?
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SIADH (syndrome of inappropriate antidiuretic hormone secretion)- What paraneoplastic syndrome results from ectopic ACTH secretion by small cell lung carcinoma?
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Cushing syndrome
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