Immunohistochemistry, FISH, and PCR-based diagnostic techniques used in modern pathology, one technique per card.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- Which IHC marker identifies epithelial cell origin in a tumor (e.g., carcinoma)?
- Cytokeratin
- Which IHC marker identifies mesenchymal cell origin (e.g., sarcoma)?
- Vimentin
- Which IHC marker indicates muscle differentiation in a tumor?
- Desmin
- Which IHC marker is positive in melanoma, schwannoma, and Langerhans cell histiocytosis?
- S-100
- Which IHC marker identifies glial cell tumors such as astrocytoma?
- GFAP (glial fibrillary acidic protein)
- Which IHC marker, also called leukocyte common antigen, marks cells of hematopoietic origin?
- CD45
- Which IHC marker identifies B lymphocytes?
- CD20
- Which IHC marker identifies T lymphocytes?
- CD3
- Which IHC marker is characteristic of lung and thyroid adenocarcinomas?
- TTF-1 (thyroid transcription factor-1)
- Which IHC marker is used to identify prostate adenocarcinoma?
- PSA (prostate-specific antigen)
- Which IHC marker identifies neuroendocrine tumors such as carcinoid and small cell carcinoma?
- Chromogranin A
- Which IHC marker, alongside chromogranin, confirms neuroendocrine differentiation?
- Synaptophysin
- Which IHC marker is specific for melanoma?
- HMB-45
- What does IHC staining for ER/PR status determine in a breast cancer specimen?
- Whether the tumor expresses estrogen and progesterone receptors, guiding hormonal therapy
- What does positive HER2 IHC staining in breast cancer indicate?
- Overexpression of the HER2/neu receptor, guiding trastuzumab therapy