Bone marrow and peripheral smear morphology for anemias, leukemias, and lymphomas, distinct from the clinical-management focus of the Hematology and Oncology deck.
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- What is the classic peripheral smear finding in iron deficiency anemia?
- Microcytic, hypochromic RBCs
- What elongated RBC shape is seen in severe iron deficiency anemia?
- Pencil cells (elliptocytes)
- What neutrophil finding is characteristic of megaloblastic anemia?
- Hypersegmented neutrophils (6+ lobes)
- What large, oval RBCs are seen in megaloblastic anemia?
- Macro-ovalocytes
- What special stain and finding confirms sideroblastic anemia?
- Ringed sideroblasts on Prussian blue (iron) stain
- What RBC morphology is seen in hereditary spherocytosis?
- Spherocytes (small, round cells lacking central pallor)
- What RBC finding is characteristic of G6PD deficiency during a hemolytic episode?
- Bite cells
- What denatured hemoglobin inclusion is seen in G6PD deficiency?
- Heinz bodies
- What RBC shape defines sickle cell anemia on smear?
- Sickle-shaped (crescent) RBCs
- What nuclear remnant appears in RBCs after splenic dysfunction, as in sickle cell disease?
- Howell-Jolly bodies
- What RBC finding is seen in thalassemia?
- Target cells
- What fragmented RBCs are seen in microangiopathic hemolytic anemia?
- Schistocytes
- What is the characteristic bone marrow finding in aplastic anemia?
- Hypocellular marrow with fatty replacement
- What teardrop-shaped RBC is seen when marrow space is infiltrated by fibrosis or tumor?
- Dacrocyte (teardrop cell)
- What RBC inclusion is characteristic of lead poisoning?
- Basophilic stippling