Granulomatous and other classic tissue response patterns to infection, distinct from the organism-identification focus of the Microbiology decks.
34 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the general term for a nodular collection of activated macrophages (epithelioid histiocytes) that forms in response to persistent, poorly degradable antigens?
Show answer
Granulomatous inflammation (granuloma)- What cell type do epithelioid histiocytes differentiate from?
Show answer
Activated macrophages- How do epithelioid histiocytes appear histologically?
Show answer
Abundant pink cytoplasm with elongated, slipper-shaped nuclei- How are the nuclei arranged in a Langhans giant cell?
Show answer
In a peripheral horseshoe or ring pattern around the edge of the cell- How are the nuclei arranged in a foreign body giant cell?
Show answer
Scattered haphazardly throughout the cytoplasm- What organism classically causes caseating granulomas?
Show answer
Mycobacterium tuberculosis- What is the gross (naked-eye) appearance of caseous necrosis?
Show answer
Soft, friable, cheese-like white-yellow material- How does caseous necrosis appear under the microscope?
Show answer
Amorphous, structureless eosinophilic debris with no visible cell outlines- What is a Ghon focus?
Show answer
A peripheral lung granuloma marking the initial site of primary tuberculosis infection- A Ghon focus plus involvement of what structure together make up a Ghon complex?
Show answer
The ipsilateral hilar lymph node- What is a Ghon complex called once it becomes calcified and fibrotic?
Show answer
Ranke complex- Describe the gross pattern of miliary tuberculosis.
Show answer
Numerous small (1-2 mm), yellow-white granulomas scattered throughout the organ- What term describes a granuloma that lacks central necrotic debris?
Show answer
Noncaseating granuloma- Which systemic disease of unknown cause classically produces noncaseating granulomas in multiple organs?
Show answer
Sarcoidosis- Which inflammatory bowel disease is associated with noncaseating granulomas in the bowel wall?
Show answer
Crohn disease
FlashKeepers