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Neurology · USMLE Step 1 · Healthcare and Nursing

USMLE Neuro

Brain/spinal tracts, classic lesions and their deficits, and high-yield neuro pathology.

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42 mixed cards for USMLE Step 1 Neurology. It opens with "Where does the corticospinal tract originate?" and "What percentage of corticospinal tract fibers decussate at the pyramids of the". Study it alongside the other USMLE Step 1 sets below.

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Where does the corticospinal tract originate?
Show answerMotor cortex (Brodmann area 4), premotor cortex (area 6), and supplementary motor area
What percentage of corticospinal tract fibers decussate at the pyramids of the medulla?
Show answerApproximately 90 percent; the remaining 10 percent descend ipsilaterally in the ventral corticospinal tract
What does a positive Babinski sign indicate?
Show answerUMN lesion, usually involving the corticospinal tract
At what level do spinothalamic tract fibers cross the midline after entering the spinal cord?
Show answer1-2 segments rostral to entry (they synapse in the dorsal horn and immediately cross)
What sensory pattern occurs with a unilateral spinothalamic tract lesion in the spinal cord?
Show answerContralateral loss of pain and temperature sensation beginning 1-2 segments below the lesion
In Brown-Sequard syndrome, what is the pattern of sensory loss?
Show answerIpsilateral loss of proprioception and vibration (dorsal columns) and contralateral loss of pain and temperature (spinothalamic tract)
Where do dorsal column fibers decussate?
Show answerIn the medulla via internal arcuate fibers that cross at the medullary pyramids
Which dorsal column tract carries lower extremity proprioception and vibration?
Show answerFasciculus gracilis (cuneatus carries upper extremity)
Which dorsal column tract carries upper extremity proprioception and vibration?
Show answerFasciculus cuneatus (gracilis carries lower extremity)
Weber syndrome results from a lesion in which part of the brainstem?
Show answerVentral midbrain, affecting CN III fascicles and the cerebral peduncle
What are the clinical findings in Weber syndrome?
Show answerIpsilateral CN III palsy (ptosis, down-and-out eye, dilated pupil) with contralateral hemiparesis
What artery occlusion causes Wallenberg syndrome (lateral medullary syndrome)?
Show answerPosterior inferior cerebellar artery (PICA), resulting in lateral medullary infarction
Claude syndrome involves a lesion of which midbrain structure?
Show answerDorsal midbrain (tegmentum), involving the red nucleus and CN III fascicles, characterized by ipsilateral CN III palsy with contralateral cerebellar signs (ataxia/tremor).
Central cord syndrome is classically caused by what mechanism?
Show answerHyperextension injury (usually in elderly with cervical spondylosis), affecting the central gray matter
What is the classic motor pattern in central cord syndrome?
Show answerDisproportionate upper extremity weakness compared to lower extremities (cape-like or sacral-sparing distribution)

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