Major autoimmune diseases matched to their characteristic autoantibody and underlying immune mechanism tested on USMLE Step 1.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- Which antibody test is the most sensitive screening test for systemic lupus erythematosus (SLE)?
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Antinuclear antibody (ANA)- Anti-double stranded DNA (anti-dsDNA) antibody
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Systemic lupus erythematosus (SLE)- Which SLE antibody is highly specific for the disease but does not track with disease activity?
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Anti-Smith (anti-Sm) antibody- Which autoantibody is characteristic of drug-induced lupus (e.g., from hydralazine or procainamide)?
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Anti-histone antibody- What type of hypersensitivity reaction underlies tissue damage in SLE?
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Type III hypersensitivity (immune complex mediated)- Anti-cyclic citrullinated peptide (anti-CCP) antibody
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Rheumatoid arthritis- What does rheumatoid factor (RF) bind to?
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The Fc portion of IgG- Which autoantibody, along with anti-La, is characteristic of Sjogren syndrome?
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Anti-Ro (SSA) antibody- Which autoantibody, along with anti-Ro, is characteristic of Sjogren syndrome?
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Anti-La (SSB) antibody- Anti-Scl-70 (anti-topoisomerase I) antibody
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Diffuse systemic sclerosis (scleroderma)- Which antibody is associated with limited systemic sclerosis (CREST syndrome)?
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Anti-centromere antibody- Which autoantibody is associated with mixed connective tissue disease?
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Anti-U1 ribonucleoprotein (anti-U1 RNP) antibody- Which autoantibody is associated with polymyositis and dermatomyositis?
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Anti-Jo-1 antibody- What immune mechanism links untreated group A streptococcal pharyngitis to rheumatic fever?
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Molecular mimicry, antibodies against the bacterial M protein cross-react with cardiac tissue- Which autoantibody is relatively specific for dermatomyositis rather than polymyositis?
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Anti-Mi-2 antibody
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