Major autoimmune diseases matched to their characteristic autoantibody and underlying immune mechanism tested on USMLE Step 1.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- Which antibody test is the most sensitive screening test for systemic lupus erythematosus (SLE)?
- Antinuclear antibody (ANA)
- Anti-double stranded DNA (anti-dsDNA) antibody
- Systemic lupus erythematosus (SLE)
- Which SLE antibody is highly specific for the disease but does not track with disease activity?
- Anti-Smith (anti-Sm) antibody
- Which autoantibody is characteristic of drug-induced lupus (e.g., from hydralazine or procainamide)?
- Anti-histone antibody
- What type of hypersensitivity reaction underlies tissue damage in SLE?
- Type III hypersensitivity (immune complex mediated)
- Anti-cyclic citrullinated peptide (anti-CCP) antibody
- Rheumatoid arthritis
- What does rheumatoid factor (RF) bind to?
- The Fc portion of IgG
- Which autoantibody, along with anti-La, is characteristic of Sjogren syndrome?
- Anti-Ro (SSA) antibody
- Which autoantibody, along with anti-Ro, is characteristic of Sjogren syndrome?
- Anti-La (SSB) antibody
- Anti-Scl-70 (anti-topoisomerase I) antibody
- Diffuse systemic sclerosis (scleroderma)
- Which antibody is associated with limited systemic sclerosis (CREST syndrome)?
- Anti-centromere antibody
- Which autoantibody is associated with mixed connective tissue disease?
- Anti-U1 ribonucleoprotein (anti-U1 RNP) antibody
- Which autoantibody is associated with polymyositis and dermatomyositis?
- Anti-Jo-1 antibody
- What immune mechanism links untreated group A streptococcal pharyngitis to rheumatic fever?
- Molecular mimicry, antibodies against the bacterial M protein cross-react with cardiac tissue
- Which autoantibody is relatively specific for dermatomyositis rather than polymyositis?
- Anti-Mi-2 antibody