Genital ridge formation, mesonephric and paramesonephric duct fates, and gonadal descent tested on USMLE Step 1.
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- What embryonic tissue gives rise to the genital ridge?
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Intermediate mesoderm- What is the 'indifferent gonad'?
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The undifferentiated gonad present in both XX and XY embryos before sex-specific differentiation begins- Which gene on the Y chromosome initiates testis development?
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SRY (sex-determining region Y)- Which fetal testicular cells secrete anti-Mullerian hormone (AMH)?
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Sertoli cells- Which fetal testicular cells secrete testosterone?
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Leydig cells- What is the main effect of anti-Mullerian hormone (AMH) on duct development?
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It causes regression of the paramesonephric (Mullerian) ducts- What hormone stimulates the mesonephric (Wolffian) ducts to develop into male internal genital structures?
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Testosterone- Mesonephric duct
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Wolffian duct- Paramesonephric duct
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Mullerian duct- What three structures does the mesonephric (Wolffian) duct give rise to in males?
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Epididymis, vas deferens, and seminal vesicle- What three structures does the paramesonephric (Mullerian) duct give rise to in females?
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Fallopian tubes, uterus, and cervix- What is the gubernaculum?
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A cord of tissue that guides descent of the gonad toward the inguinal region- In males, what does the gubernaculum become?
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A ligament anchoring the testis within the scrotum- In females, what does the proximal part of the gubernaculum become?
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The ovarian ligament- In females, what does the distal part of the gubernaculum become?
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The round ligament of the uterus
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