Genital ridge formation, mesonephric and paramesonephric duct fates, and gonadal descent tested on USMLE Step 1.
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- What embryonic tissue gives rise to the genital ridge?
- Intermediate mesoderm
- What is the 'indifferent gonad'?
- The undifferentiated gonad present in both XX and XY embryos before sex-specific differentiation begins
- Which gene on the Y chromosome initiates testis development?
- SRY (sex-determining region Y)
- Which fetal testicular cells secrete anti-Mullerian hormone (AMH)?
- Sertoli cells
- Which fetal testicular cells secrete testosterone?
- Leydig cells
- What is the main effect of anti-Mullerian hormone (AMH) on duct development?
- It causes regression of the paramesonephric (Mullerian) ducts
- What hormone stimulates the mesonephric (Wolffian) ducts to develop into male internal genital structures?
- Testosterone
- Mesonephric duct
- Wolffian duct
- Paramesonephric duct
- Mullerian duct
- What three structures does the mesonephric (Wolffian) duct give rise to in males?
- Epididymis, vas deferens, and seminal vesicle
- What three structures does the paramesonephric (Mullerian) duct give rise to in females?
- Fallopian tubes, uterus, and cervix
- What is the gubernaculum?
- A cord of tissue that guides descent of the gonad toward the inguinal region
- In males, what does the gubernaculum become?
- A ligament anchoring the testis within the scrotum
- In females, what does the proximal part of the gubernaculum become?
- The ovarian ligament
- In females, what does the distal part of the gubernaculum become?
- The round ligament of the uterus