A condensed rapid review pass over the highest yield reproductive endocrinology and pathology facts for final week review.
40 cards · mixed cards · AI-written, checked twice. Edit anything.
- What effect does pulsatile GnRH secretion have on the anterior pituitary?
Show answer
It stimulates LH and FSH release- What happens to LH and FSH secretion when GnRH is given continuously instead of pulsatile?
Show answer
Secretion is suppressed (GnRH receptor downregulation)- What event triggers ovulation?
Show answer
The LH surge- In the two-cell, two-gonadotropin theory, LH stimulates theca cells to make androgens, which granulosa cells then ____ under FSH stimulation.
Show answer
aromatize into estrogen- What hormone from granulosa cells (and Sertoli cells) selectively suppresses FSH secretion?
Show answer
Inhibin B- What protein do Sertoli cells secrete to keep local testosterone concentrations high for spermatogenesis?
Show answer
Androgen-binding protein- Which testicular cells produce testosterone in response to LH?
Show answer
Leydig cells- What structural feature do hCG, LH, FSH, and TSH share?
Show answer
An identical alpha subunit (each has a unique beta subunit for specificity)- 5-alpha-reductase deficiency: genotype and typical genital appearance at birth?
Show answer
46,XY with ambiguous or female-appearing external genitalia (normal testosterone, low DHT)- Complete androgen insensitivity syndrome: genotype and phenotype?
Show answer
46,XY with testes present, female external genitalia, and an absent uterus with a blind-ending vaginal pouch- What is the most common cause of congenital adrenal hyperplasia?
Show answer
21-hydroxylase deficiency- How does classic 21-hydroxylase deficiency present in genetic female infants?
Show answer
Ambiguous genitalia from androgen excess, often with salt-wasting- Klinefelter syndrome (47,XXY): key clinical features?
Show answer
Testicular atrophy, gynecomastia, and infertility- Turner syndrome (45,X0): key clinical features?
Show answer
Streak ovaries, short stature, and webbed neck- What are the Rotterdam criteria for diagnosing PCOS?
Show answer
2 of 3: oligo/anovulation, clinical or biochemical hyperandrogenism, and polycystic ovaries on ultrasound
FlashKeepers