Lead, mercury, arsenic, and other heavy metal poisoning presentations and chelation treatment concepts.
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- What blood smear finding is classically associated with lead poisoning?
- Basophilic stippling of red blood cells
- What GI symptom is classically caused by lead poisoning?
- Abdominal pain (lead colic)
- What neurodevelopmental effect does lead poisoning have in children?
- Developmental delay and cognitive impairment
- What oral finding, a blue-gray line at the gumline, is seen in chronic lead poisoning?
- Burton's line
- What classic peripheral motor finding results from lead-induced radial nerve damage?
- Wrist drop
- What two chelators are used together for severe (encephalopathic) lead poisoning?
- Dimercaprol (BAL) and calcium disodium EDTA
- What oral chelating agent is used for mild to moderate childhood lead poisoning?
- Succimer (DMSA)
- What is a common historical source of childhood lead poisoning?
- Lead-based paint chips in old homes
- What kidney condition can chronic lead exposure cause?
- Proximal tubular damage resembling Fanconi syndrome
- What classic symptom triad suggests mercury poisoning?
- Erethism (irritability or mood change), tremor, and gingivitis
- What form of mercury accumulates in fish and causes poisoning when eaten?
- Methylmercury (organic mercury)
- What historical illness is nicknamed for mercury exposure in the felt hat industry?
- Mad hatter disease
- What disease resulted from methylmercury-contaminated industrial wastewater in Japan?
- Minamata disease
- What chelators treat inorganic mercury poisoning?
- Dimercaprol (BAL) or succimer (DMSA)
- What condition, marked by pink, painful extremities, occurs in children with mercury exposure?
- Acrodynia (pink disease)