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Nursing Pharmacology · NCLEX-RN

Nursing Pharmacology: IV Fluids and Electrolyte Replacement

Isotonic, hypotonic, and hypertonic IV fluid types and electrolyte replacement therapy with their key nursing considerations.

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How does the osmolality of an isotonic IV solution compare to plasma?
It is approximately equal to plasma osmolality
Name a commonly used isotonic IV fluid
0.9% NaCl (normal saline)
Name a second commonly used isotonic IV fluid
Lactated Ringer's solution
What is the primary clinical use of isotonic IV fluids?
To expand extracellular fluid volume, such as in hypovolemia or hemorrhage
What is the main nursing risk of infusing large volumes of isotonic fluid?
Fluid (circulatory) overload
How does the osmolality of a hypotonic IV solution compare to plasma?
It is lower than plasma osmolality
Name a commonly used hypotonic IV fluid
0.45% NaCl (half-normal saline)
What is the primary clinical use of hypotonic IV fluids?
To treat cellular dehydration/hypernatremia by shifting water into cells
What is the main nursing risk of hypotonic IV fluids?
Cell swelling, including risk of cerebral edema
How does the osmolality of a hypertonic IV solution compare to plasma?
It is higher than plasma osmolality
Name a hypertonic IV fluid used for severe hyponatremia
3% NaCl (hypertonic saline)
Name a dextrose-containing hypertonic IV fluid
D5 0.9% NaCl (D5NS)
What is the primary clinical use of hypertonic IV fluids?
Treating severe hyponatremia and cerebral edema by pulling fluid into the vascular space
What is a key nursing precaution when administering hypertonic saline?
Infuse slowly via pump and monitor closely for fluid overload
Why is D5W considered physiologically hypotonic even though it is isotonic in the bag?
The dextrose is metabolized quickly, leaving behind free water that dilutes plasma

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