Vaughan Williams classes, amiodarone and adenosine, vasopressors and inotropes, titration endpoints and monitoring.
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- Which Vaughan Williams class includes sodium channel blockers?
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Class I- What effect do Class IA antiarrhythmics have on action potential duration?
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They prolong it- Name a classic Class IA antiarrhythmic drug.
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Procainamide- What is a major risk of Class IA antiarrhythmics like quinidine and procainamide?
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QT prolongation leading to torsades de pointes- Name a Class IB antiarrhythmic.
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Lidocaine- Class IB antiarrhythmics are most useful for treating which type of arrhythmia?
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Ventricular arrhythmias, especially after a myocardial infarction- Name a Class IC antiarrhythmic.
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Flecainide- Why are Class IC antiarrhythmics avoided in patients with structural heart disease or a prior MI?
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They increase the risk of proarrhythmia and mortality in that population- What is the mechanism of Class II antiarrhythmics?
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Beta-adrenergic receptor blockade, decreasing SA and AV node automaticity and conduction- Name a Class II antiarrhythmic.
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Metoprolol- What is the mechanism of Class III antiarrhythmics?
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Potassium channel blockade that prolongs repolarization and the QT interval- Which drug is the prototype Class III antiarrhythmic?
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Amiodarone- What is the mechanism of Class IV antiarrhythmics?
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Calcium channel blockade that slows conduction through the AV node- Name the two main Class IV antiarrhythmics.
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Verapamil and diltiazem- What early symptoms suggest amiodarone-induced pulmonary toxicity?
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New dyspnea and a dry cough
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