GI hormone regulation, motility mechanisms, and digestive and absorptive processes tested on USMLE Step 1.
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- Where are gastrin-secreting G cells located?
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Antrum of the stomach
- What is the primary action of gastrin?
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Stimulates parietal cells to secrete HCl (gastric acid)
- What stimulates gastrin secretion?
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Vagal stimulation, stomach distention, and luminal peptides/amino acids
- Where are CCK-secreting I cells located?
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Duodenum and jejunum
- What effect does CCK have on the gallbladder?
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Stimulates gallbladder contraction
- What effect does CCK have on the pancreas?
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Stimulates secretion of pancreatic digestive enzymes
- What stimulates CCK secretion?
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Fatty acids and amino acids in the duodenum
- Where are secretin-secreting S cells located?
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Duodenum
- What effect does secretin have on the pancreas?
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Stimulates secretion of bicarbonate-rich fluid from pancreatic ducts
- What effect does secretin have on gastric acid secretion?
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Inhibits it
- What stimulates secretin secretion?
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Acid (low pH) in the duodenum
- What is the main effect of GIP (glucose-dependent insulinotropic peptide)?
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Stimulates insulin release from the pancreas
- What is the main function of motilin?
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Stimulates migrating motor complexes during fasting
- What is the main function of somatostatin in the GI tract?
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Inhibits secretion of gastric acid and virtually all other GI hormones
- What is the main action of vasoactive intestinal peptide (VIP)?
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Relaxes GI smooth muscle and sphincters, and stimulates intestinal secretion