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Biostatistics · Biostatistics Fundamentals

Biostatistics: Diagnostic Test Performance

Positive and negative predictive value, likelihood ratios, and ROC curve interpretation as cloze cards with each formula and term defined.

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Sensitivity is the proportion of people with the disease who test ____.
positive
Specificity is the proportion of people without the disease who test ____.
negative
Positive predictive value (PPV) is the proportion of people with a ____ test result who actually have the disease.
positive
Negative predictive value (NPV) is the proportion of people with a ____ test result who actually do not have the disease.
negative
PPV equals true positives divided by ____.
(true positives + false positives)
NPV equals true negatives divided by ____.
(true negatives + false negatives)
Sensitivity equals true positives divided by ____.
(true positives + false negatives)
Specificity equals true negatives divided by ____.
(true negatives + false positives)
If disease prevalence increases while sensitivity and specificity stay fixed, what happens to PPV?
PPV increases
If disease prevalence increases while sensitivity and specificity stay fixed, what happens to NPV?
NPV decreases
Sensitivity and specificity are intrinsic test properties that do ____ change with disease prevalence.
not
The positive likelihood ratio (LR+) equals sensitivity divided by ____.
(1 - specificity)
The negative likelihood ratio (LR-) equals (1 - sensitivity) divided by ____.
specificity
An LR+ greater than ____ increases the probability that a patient has the disease.
1
An LR- less than ____ decreases the probability that a patient has the disease.
1

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