Biostatistics · USMLE Step 1

USMLE Biostatistics

Core biostatistics and epidemiology formulas including sensitivity, specificity, relative risk, and study design, as cloze cards with each term defined.

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Sensitivity is calculated as ____.
true positives / (true positives + false negatives)
Specificity is calculated as ____.
true negatives / (true negatives + false positives)
Positive predictive value (PPV) is calculated as ____.
true positives / (true positives + false positives)
Negative predictive value (NPV) is calculated as ____.
true negatives / (true negatives + false negatives)
A highly sensitive test, when its result is negative, is used to ____ disease (mnemonic SnNout).
rule out
A highly specific test, when its result is positive, is used to ____ disease (mnemonic SpPin).
rule in
Prevalence is defined as the ____.
proportion of a population that has a disease at a given point in time
Incidence is defined as the ____.
rate at which new cases of a disease occur in a population over a specified time period
How does positive predictive value change as disease prevalence increases, if a test's sensitivity and specificity stay constant?
PPV increases
How does negative predictive value change as disease prevalence increases, if a test's sensitivity and specificity stay constant?
NPV decreases
Relative risk is calculated as ____.
incidence in the exposed group divided by incidence in the unexposed group
Relative risk is the primary risk measure calculated in which type of study design?
Cohort study
In a 2x2 exposure/disease table with cells a, b, c, d, the odds ratio is calculated as ____.
(a x d) / (b x c)
An odds ratio closely approximates relative risk under what condition?
When the disease being studied is rare.
Odds ratio is the primary risk measure calculated in which type of study design?
Case-control study

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