Biostatistics · USMLE Step 1

USMLE Biostatistics: Study Design and Bias

Study design types, sources of bias, and confounding concepts tested on USMLE Step 1, as cloze cards with each term defined.

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A study that compares patients with a disease (cases) to those without (controls) and looks backward for exposure is called a ____.
case-control study
A study that follows a group of exposed and unexposed individuals forward in time to see who develops disease is called a ____.
cohort study
In a case-control study, the measure of association typically calculated is the ____.
odds ratio
In a cohort study, the measure of association typically calculated is the ____ (risk ratio).
relative risk
A study in which subjects are randomly assigned to receive an intervention or a control is called a ____.
randomized controlled trial
A study that assesses exposure and disease status at a single point in time is called a ____.
cross-sectional study
Cross-sectional studies measure disease ____ rather than incidence.
prevalence
A descriptive study that reports on a group of patients with a similar diagnosis without a comparison group is called a ____.
case series
A study that compares disease rates and exposures across entire populations or groups rather than individuals is called an ____.
ecological study
The error of assuming that an association observed at the group level also holds true at the individual level is called the ____.
ecological fallacy
Nonrandom sampling of subjects that produces a study population unrepresentative of the target population is called ____.
selection bias
A type of selection bias that arises when hospitalized subjects are used as controls, creating a false association between exposure and disease, is called ____.
Berkson bias
The tendency for employed populations to show lower mortality than the general population, a form of selection bias, is called the ____.
healthy worker effect
Systematic error arising because subjects with a disease more accurately remember past exposures than healthy subjects is called ____.
recall bias
Recall bias is a particular concern in ____ studies because exposure data is collected retrospectively.
case-control

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