Obstetrics and Gynecology · USMLE Step 2 CK

USMLE Step 2 CK Gynecology: Oncology and Reproductive Endocrinology

Gynecologic cancer screening and staging plus PCOS and infertility workup scenarios beyond the general OB/GYN deck.

35 cards · basic cards · AI-written, checked twice. Edit anything.

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At what age does routine cervical cancer screening typically begin in average-risk women?
Age 21
For average-risk women ages 21 to 29, how often should cervical cytology (Pap smear alone) be performed?
Every 3 years
For average-risk women ages 30 to 65, what is a preferred cervical cancer screening strategy?
Co-testing with Pap smear and HPV testing every 5 years
At what age can cervical cancer screening generally be stopped, given adequate prior negative screening?
Age 65
Which two HPV genotypes carry the highest risk for cervical cancer?
HPV 16 and 18
What is the most common histologic type of cervical cancer?
Squamous cell carcinoma
Unlike most gynecologic cancers, how is cervical cancer primarily staged?
Clinically (FIGO clinical staging), not surgically
What defines FIGO stage I cervical cancer?
Tumor confined to the cervix
What is the standard management for biopsy-confirmed high-grade cervical intraepithelial neoplasia (CIN 2/3)?
Excisional procedure such as LEEP or cold-knife cone biopsy
What is the most common presenting symptom of endometrial cancer?
Postmenopausal bleeding
What is a major risk factor for endometrial cancer related to hormone exposure?
Unopposed estrogen exposure
What is the most common histologic subtype of endometrial cancer?
Endometrioid adenocarcinoma
What is the first-line imaging test for a woman with postmenopausal bleeding?
Transvaginal ultrasound
What endometrial stripe thickness on transvaginal ultrasound warrants endometrial biopsy in a postmenopausal woman?
Greater than 4 mm
What test provides the definitive diagnosis of endometrial cancer?
Endometrial biopsy

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