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Immunology · USMLE Step 1 · Healthcare and Nursing

USMLE Immunology: Cytokines and Cell Signaling

Key cytokines, their producing and target cells, and the immune process each one drives, one cytokine per card.

About this set

31 basic cards for USMLE Step 1 Immunology. Set 5 of 10 in USMLE Immunology. It opens with "Which cells are the primary source of IL-1?" and "Which cells primarily secrete IL-2?". Study it alongside the other USMLE Step 1 sets below.

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Which cells are the primary source of IL-1?
Show answerActivated macrophages (and other antigen-presenting cells).
Which cells primarily secrete IL-2?
Show answerActivated CD4+ T cells (Th1 cells).
What is the main function of IL-2?
Show answerStimulates proliferation of T cells and NK cells.
Which cells are the main producers of IL-4?
Show answerTh2 cells.
Which cells primarily produce IL-5?
Show answerTh2 cells.
Which cells produce IL-6?
Show answerMacrophages and Th2 cells.
Which cells are the main source of IL-8?
Show answerMacrophages.
What is the main function of IL-8?
Show answerChemoattractant that recruits neutrophils to sites of infection.
Which cells are the main source of IL-10?
Show answerRegulatory T cells (and Th2 cells).
Which cells are the main source of IL-12?
Show answerMacrophages and dendritic cells.
Which cells primarily produce IL-13?
Show answerTh2 cells.
Which cells produce IL-17?
Show answerTh17 cells.
What is the main function of IL-17?
Show answerRecruits neutrophils by inducing chemokine and G-CSF production.
Which cells are the primary source of TNF-alpha?
Show answerActivated macrophages.
Which cells are the main source of IFN-gamma?
Show answerTh1 cells and NK cells.

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