A condensed rapid review pass over the highest yield innate and adaptive immunology facts for final week review.
35 cards · mixed cards · AI-written, checked twice. Edit anything.
- The dominant leukocyte recruited during the first 24 to 48 hours of acute inflammation is the ____.
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neutrophil- What is the main phagocytic cell that also presents antigen to T cells during a chronic immune response?
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Macrophage- How does a natural killer (NK) cell recognize a virus-infected or tumor cell as a target?
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It detects the absence (downregulation) of MHC class I on the cell surface (missing self)- What triggers activation of the classical complement pathway?
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Antibody (IgG or IgM) bound to antigen- What triggers activation of the alternative complement pathway?
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Direct contact with a microbial cell surface, without antibody- What molecule triggers the lectin complement pathway?
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Mannose-binding lectin binding to mannose residues on a microbial surface- Which complement protein acts as the major opsonin, coating pathogens for phagocytosis?
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C3b- Which complement protein is the most potent chemoattractant for neutrophils and also acts as an anaphylatoxin?
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C5a- The complement proteins C5b through C9 assemble into the ____, which lyses target cells, especially gram-negative bacteria.
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membrane attack complex- What family of innate immune receptors recognizes conserved pathogen-associated molecular patterns (PAMPs)?
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Toll-like receptors (TLRs)- What cytokines are released by virus-infected cells to induce an antiviral state in neighboring uninfected cells?
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Type I interferons (IFN-alpha and IFN-beta)- What triggers mast cells to degranulate and release histamine in an allergic reaction?
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Cross-linking of surface-bound IgE by antigen- CD4
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Co-receptor on helper T cells that binds MHC class II- CD8
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Co-receptor on cytotoxic T cells that binds MHC class I- Which cells express MHC class I molecules?
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Nearly all nucleated cells
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