Anemias, coagulation disorders, leukemias and lymphomas, and classic tumor markers tested on USMLE Step 1.
About this set
45 mixed cards for USMLE Step 1 Hematology and Oncology. It opens with "What is the MCV classification (microcytic, normocytic, or macrocytic) of iron" and "In iron deficiency anemia, how do serum ferritin and TIBC change?". Study it alongside the other USMLE Step 1 sets below.
45 cards · mixed cards · AI-written, checked twice. Edit anything.
- What is the MCV classification (microcytic, normocytic, or macrocytic) of iron deficiency anemia?
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Microcytic- In iron deficiency anemia, how do serum ferritin and TIBC change?
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Ferritin decreases; TIBC (total iron binding capacity) increases- What red blood cell finding on peripheral smear is characteristic of thalassemia?
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Target cells- What bone marrow finding defines sideroblastic anemia?
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Ringed sideroblasts (erythroblasts with iron laden mitochondria encircling the nucleus)- What peripheral smear finding is classically seen in lead poisoning?
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Basophilic stippling of red blood cells- In megaloblastic anemia, neutrophils show ____ (nuclei with 6 or more lobes).
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hypersegmentation- What is the mechanism of pernicious anemia?
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Autoantibodies against intrinsic factor or gastric parietal cells impair vitamin B12 absorption- Unlike vitamin B12 deficiency, folate deficiency does not cause ____.
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neurologic symptoms- What happens to serum haptoglobin during hemolysis?
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It decreases, since it is consumed binding free hemoglobin- What single amino acid substitution causes sickle cell disease?
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Glutamic acid is replaced by valine at position 6 of the beta-globin chain- What red cell membrane protein defect underlies hereditary spherocytosis?
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Deficiency of spectrin or ankyrin- What peripheral smear findings are seen in G6PD deficiency during an oxidative stress episode?
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Heinz bodies and bite cells- What test detects antibodies bound to a patient's own red blood cells in autoimmune hemolytic anemia?
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Direct Coombs test (direct antiglobulin test)- What clotting factor is deficient in Hemophilia A?
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Factor VIII- In hemophilia, what happens to PT and PTT?
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PTT is prolonged; PT is normal
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