Leukemia and lymphoma subtype classification, characteristic cytogenetics, and distinguishing clinical features, one subtype per card.
40 cards · basic cards · AI-written, checked twice. Edit anything.
- In chronic myeloid leukemia (CML), the ____ translocation produces the Philadelphia chromosome.
- t(9;22) BCR-ABL
- What physical exam finding is classically massive in chronic myeloid leukemia?
- Splenomegaly
- What complication can chronic myeloid leukemia progress to over time?
- Blast crisis (transformation to acute leukemia)
- Acute promyelocytic leukemia (AML M3) is characterized by the ____ translocation.
- t(15;17) PML-RARA
- What life-threatening coagulopathy is classically associated with acute promyelocytic leukemia?
- Disseminated intravascular coagulation (DIC)
- What rod-shaped cytoplasmic inclusions are seen in acute promyelocytic leukemia blasts?
- Auer rods
- What characteristic artifact appears on peripheral blood smear in chronic lymphocytic leukemia?
- Smudge cells
- Which two CD markers are co-expressed on the malignant B cells of chronic lymphocytic leukemia?
- CD5 and CD23
- What is it called when CLL transforms into an aggressive diffuse large B-cell lymphoma?
- Richter transformation
- What special cytochemical stain is classically positive in hairy cell leukemia?
- Tartrate-resistant acid phosphatase (TRAP)
- Hairy cell leukemia typically causes splenomegaly without which other common leukemic finding?
- Lymphadenopathy
- Bone marrow aspiration in hairy cell leukemia often yields what result due to marrow fibrosis?
- A dry tap
- Burkitt lymphoma is driven by the ____ translocation, placing MYC under control of the immunoglobulin heavy chain promoter.
- t(8;14)
- What histologic pattern, caused by macrophages engulfing apoptotic tumor cells among sheets of lymphocytes, is seen in Burkitt lymphoma?
- Starry sky pattern
- The endemic (African) form of Burkitt lymphoma, associated with EBV, classically presents with a mass in what location?
- The jaw