Leukemia and lymphoma subtype classification, characteristic cytogenetics, and distinguishing clinical features, one subtype per card.
About this set
40 basic cards for USMLE Step 1 Hematology and Oncology. Set 2 of 2 in USMLE Hematology. It opens with "In chronic myeloid leukemia (CML), the ____ translocation produces the" and "What physical exam finding is classically massive in chronic myeloid leukemia?". Study it alongside the other USMLE Step 1 sets below.
40 cards · basic cards · AI-written, checked twice. Edit anything.
- In chronic myeloid leukemia (CML), the ____ translocation produces the Philadelphia chromosome.
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t(9;22) BCR-ABL- What physical exam finding is classically massive in chronic myeloid leukemia?
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Splenomegaly- What complication can chronic myeloid leukemia progress to over time?
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Blast crisis (transformation to acute leukemia)- Acute promyelocytic leukemia (AML M3) is characterized by the ____ translocation.
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t(15;17) PML-RARA- What life-threatening coagulopathy is classically associated with acute promyelocytic leukemia?
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Disseminated intravascular coagulation (DIC)- What rod-shaped cytoplasmic inclusions are seen in acute promyelocytic leukemia blasts?
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Auer rods- What characteristic artifact appears on peripheral blood smear in chronic lymphocytic leukemia?
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Smudge cells- Which two CD markers are co-expressed on the malignant B cells of chronic lymphocytic leukemia?
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CD5 and CD23- What is it called when CLL transforms into an aggressive diffuse large B-cell lymphoma?
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Richter transformation- What special cytochemical stain is classically positive in hairy cell leukemia?
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Tartrate-resistant acid phosphatase (TRAP)- Hairy cell leukemia typically causes splenomegaly without which other common leukemic finding?
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Lymphadenopathy- Bone marrow aspiration in hairy cell leukemia often yields what result due to marrow fibrosis?
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A dry tap- Burkitt lymphoma is driven by the ____ translocation, placing MYC under control of the immunoglobulin heavy chain promoter.
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t(8;14)- What histologic pattern, caused by macrophages engulfing apoptotic tumor cells among sheets of lymphocytes, is seen in Burkitt lymphoma?
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Starry sky pattern- The endemic (African) form of Burkitt lymphoma, associated with EBV, classically presents with a mass in what location?
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The jaw
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