Homeobox genes, developmental signaling pathways, and gene mutations that alter embryonic development.
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- What is the basic premise underlying developmental genetics?
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Development is driven by differential gene expression rather than differences in the DNA content of cells- What DNA sequence found in many developmental control genes encodes a protein domain that binds DNA to regulate transcription?
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The homeobox- What protein domain is encoded by the homeobox sequence?
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The homeodomain- What family of homeobox-containing genes controls the anterior-posterior body plan across many animal species?
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Hox genes- What term describes the phenomenon where the order of Hox genes along the chromosome matches the order of body segments they regulate along the body axis?
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Colinearity- Are Hox gene clusters and their body-patterning function highly conserved across distantly related animal species?
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Yes, Hox genes and their general function are remarkably conserved from insects to mammals- What term describes a homeotic mutation in fruit flies that causes legs to grow in place of antennae?
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The Antennapedia mutation- What term describes a classic Drosophila homeotic mutation that produces an extra pair of wings?
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The bithorax mutation- What term describes a diffusible signaling molecule whose concentration gradient provides positional information to developing cells?
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A morphogen- What classic Drosophila maternal effect gene product forms an anterior-to-posterior concentration gradient that establishes the embryo's head-to-tail axis?
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Bicoid protein- What theoretical model describes how cells interpret different morphogen concentration thresholds to adopt different fates, illustrated with colored zones?
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The French flag model- What class of genes are expressed maternally and deposited in the egg before fertilization to establish initial polarity in the embryo?
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Maternal effect genes- What class of zygotic genes divides the fruit fly embryo into broad regions along the anterior-posterior axis, acting after maternal genes?
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Gap genes- What class of segmentation genes divides the fly embryo into a repeating pattern of segments, roughly every other segment?
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Pair-rule genes- What class of segmentation genes establishes the anterior-posterior pattern within each individual segment?
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Segment polarity genes
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