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Internal Medicine · USMLE Step 3

USMLE Step 3 Palliative and End-of-Life Care

Palliative care principles, hospice criteria, and end-of-life decision making as tested on USMLE Step 3.

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A patient is eligible for the Medicare hospice benefit if their life expectancy is ____, assuming the disease runs its normal course.
6 months or less
How many benefit periods make up the initial structure of the Medicare hospice benefit before ongoing recertification?
Two initial 90-day periods, followed by an unlimited number of 60-day periods (each requiring recertification of terminal prognosis).
How does palliative care differ from hospice care in terms of required prognosis?
Palliative care can be offered at any stage of a serious illness regardless of prognosis, while hospice requires a prognosis of 6 months or less.
On the WHO analgesic ladder, what type of medication is used first for mild pain?
A nonopioid analgesic, such as acetaminophen or an NSAID.
On the WHO analgesic ladder, what is added for moderate pain not controlled by a nonopioid alone?
A mild (weak) opioid, such as codeine or tramadol, often combined with the nonopioid.
On the WHO analgesic ladder, what class of drug is used for severe pain?
A strong opioid, such as morphine.
What is the approximate oral-to-intravenous morphine conversion ratio?
About 3:1 (3 mg oral morphine is roughly equivalent to 1 mg IV morphine).
Fentanyl patches should not be used to start opioid therapy in ____ patients because of the risk of fatal respiratory depression.
opioid-naive
Which opioid, used for both pain control and addiction treatment, carries a notable risk of QT interval prolongation?
Methadone.
Does tolerance develop to the constipating effect of chronic opioid use?
No, tolerance to opioid-induced constipation does not develop, so prophylaxis should continue for as long as the opioid is used.
What type of laxative is first-line for preventing opioid-induced constipation?
A stimulant laxative, such as senna, often paired with a stool softener.
In a patient on chronic opioids who develops mild respiratory depression, why is full-dose naloxone avoided?
It can precipitate severe pain and acute opioid withdrawal; small, titrated doses are used instead if reversal is needed.
What is the first-line pharmacologic agent for treating terminal delirium?
Haloperidol, a low-dose antipsychotic.
Why are benzodiazepines generally avoided as first-line therapy for delirium in most palliative patients?
They can worsen confusion and paradoxically increase agitation.
What class of medication is used to reduce noisy respiratory secretions ('death rattle') near the end of life?
Anticholinergic agents, such as scopolamine or glycopyrrolate.

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