Allergic disease and clinical immunology topics for the outpatient internist, as tested on USMLE Step 2 CK.
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- What is the first-line treatment for anaphylaxis?
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Intramuscular epinephrine- What is the preferred injection site for epinephrine in anaphylaxis?
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Anterolateral thigh (vastus lateralis muscle)- Which antibody class mediates anaphylaxis?
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IgE- What type of hypersensitivity reaction is anaphylaxis?
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Type I (immediate, IgE-mediated)- What is a Type II hypersensitivity reaction?
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Antibody-mediated cytotoxic reaction against cell surface antigens- What is a Type III hypersensitivity reaction?
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Immune complex-mediated reaction- What is a Type IV hypersensitivity reaction?
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Delayed, T-cell mediated reaction- What is the classic symptom triad of serum sickness?
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Fever, rash, and arthralgia- How long after antigen exposure do serum sickness symptoms typically appear?
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1 to 2 weeks- What molecule accumulates to cause ACE inhibitor-induced angioedema?
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Bradykinin- Which protein is deficient or dysfunctional in hereditary angioedema?
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C1 esterase inhibitor- What is the inheritance pattern of hereditary angioedema?
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Autosomal dominant- What complement level is characteristically low during a hereditary angioedema attack?
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C4- What is used to treat an acute hereditary angioedema attack?
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C1 inhibitor concentrate- Hereditary angioedema attacks are typically unresponsive to ____.
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epinephrine, antihistamines, and corticosteroids
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