A condensed rapid review pass over the highest yield neurology and psychiatry facts for final week review.
40 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the most common cause of dementia overall?
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Alzheimer's disease- What are the two hallmark pathologic findings in Alzheimer's disease?
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Extracellular amyloid-beta plaques and intracellular neurofibrillary tangles (tau)- Parkinson's disease results from degeneration of dopaminergic neurons in which structure?
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Substantia nigra pars compacta- What intracellular inclusion is characteristic of Parkinson's disease?
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Lewy bodies (alpha-synuclein aggregates)- Huntington's disease is caused by expansion of which trinucleotide repeat, on which chromosome?
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CAG repeat expansion on chromosome 4- Huntington's disease classically causes atrophy of which brain structure?
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Caudate nucleus- What CSF finding supports a diagnosis of multiple sclerosis?
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Oligoclonal bands- What eye finding is classically associated with multiple sclerosis?
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Optic neuritis- Amyotrophic lateral sclerosis (ALS) affects ____ without sensory involvement.
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both upper and lower motor neurons- In myasthenia gravis, autoantibodies target which receptor?
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Postsynaptic acetylcholine receptor (nicotinic)- How does fatigability differ between myasthenia gravis and Lambert-Eaton syndrome?
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Myasthenia gravis worsens with repeated use; Lambert-Eaton syndrome improves with repeated use- In Lambert-Eaton myasthenic syndrome, autoantibodies target which structure?
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Presynaptic voltage-gated calcium channels- Lambert-Eaton myasthenic syndrome is most often a paraneoplastic syndrome associated with which cancer?
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Small cell lung cancer- Guillain-Barre syndrome classically presents with what pattern of weakness?
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Ascending, symmetric weakness- Guillain-Barre syndrome is most commonly preceded by infection with which organism?
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Campylobacter jejuni
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