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Physiology · USMLE Step 1 · Healthcare and Nursing

USMLE Physiology High-Yield Rapid Review

A condensed rapid review pass over the highest yield physiology mechanisms and equations for final week review.

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40 mixed cards for USMLE Step 1 Physiology. It opens with "What is the formula for cardiac output?" and "What is preload?". Study it alongside the other USMLE Step 1 sets below.

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What is the formula for cardiac output?
Show answerCO = stroke volume x heart rate
What is preload?
Show answerThe ventricular wall tension (stretch) at the end of diastole, approximated by end-diastolic volume
What is afterload?
Show answerThe resistance the ventricle must overcome to eject blood, approximated by arterial pressure
According to the Frank-Starling law, increased venous return increases ____ by increasing myocardial stretch.
Show answerstroke volume
What is the formula for mean arterial pressure (MAP)?
Show answerMAP = diastolic pressure + 1/3(systolic pressure - diastolic pressure)
What is the formula for ejection fraction?
Show answerEF = stroke volume / end-diastolic volume
What effect does vagal (parasympathetic) stimulation have on the SA node?
Show answerDecreases heart rate by hyperpolarizing SA node cells and slowing phase 4 depolarization
SA node
Show answerThe pacemaker of the heart, located in the right atrium
In capillary filtration, what does an increase in capillary hydrostatic pressure do to net filtration?
Show answerIncreases net filtration out of the capillary
What is the baroreceptor reflex response to a sudden drop in blood pressure?
Show answerDecreased baroreceptor firing triggers increased sympathetic outflow, raising heart rate and vascular resistance
A rightward shift of the oxygen-hemoglobin dissociation curve is caused partly by increased ____.
Show answer2,3-DPG
What does a rightward shift of the oxygen-hemoglobin dissociation curve do to hemoglobin's oxygen affinity?
Show answerDecreases hemoglobin's affinity for oxygen, favoring unloading to tissues
What is the Bohr effect?
Show answerIncreased CO2 and decreased pH shift the oxygen-hemoglobin curve right, promoting oxygen unloading in tissues
How does the V/Q ratio compare between the apex and base of the lung in an upright person?
Show answerThe apex has a higher V/Q ratio than the base
What is physiologic dead space?
Show answerThe sum of anatomic dead space plus alveolar dead space (ventilated but not perfused alveoli)

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