CKD staging by GFR and albuminuria, anemia of CKD, secondary hyperparathyroidism, phosphate binders, vitamin D analogs, and progression slowing therapy such as SGLT2 inhibitors and ACE inhibitors.
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- What is the clinical definition of chronic kidney disease (CKD)?
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Abnormalities of kidney structure or function present for more than 3 months
- CKD stage G1: what is the GFR range?
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GFR of 90 or higher (mL/min/1.73m2)
- CKD stage G2: what is the GFR range?
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GFR of 60 to 89
- CKD stage G3a: what is the GFR range?
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GFR of 45 to 59
- CKD stage G3b: what is the GFR range?
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GFR of 30 to 44
- CKD stage G4: what is the GFR range?
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GFR of 15 to 29
- CKD stage G5: what is the GFR range and alternate name?
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GFR less than 15; called kidney failure
- Albuminuria category A1: what is the urine albumin-to-creatinine ratio range?
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Less than 30 mg/g
- Albuminuria category A2: what is the urine albumin-to-creatinine ratio range?
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30 to 300 mg/g
- Albuminuria category A3: what is the urine albumin-to-creatinine ratio range?
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Greater than 300 mg/g
- What spot urine test is preferred over a 24 hour collection to quantify albuminuria?
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Urine albumin-to-creatinine ratio (ACR)
- What is the main cause of anemia in CKD?
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Reduced erythropoietin production by the kidneys
- At roughly which CKD stage does anemia typically become apparent?
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Stage G3
- Name two erythropoiesis-stimulating agents (ESAs) used to treat anemia of CKD.
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Epoetin alfa and darbepoetin alfa
- What is the target hemoglobin range when treating anemia of CKD with an ESA?
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About 10 to 11.5 g/dL